Haplotypes of the low-density lipoprotein receptor-related protein 5 (LRP5) gene: Are they a risk factor in osteoarthritis?

Smith, Andrew J.; Gidley, J.; Sandy, JR; Perry, Mark; Elson, C. J.; Kirwan, John R.; Spector, Tim D.; Doherty, Michael; Bidwell, Jeff L.; Mansell, Jason P.

doi:10.1016/j.joca.2005.01.008

Cited by 50 publications

(37 citation statements)

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“…In osteoblasts, LRP5 can transduce canonical signals to promote the renewal of stem cells, the stimulation of pre-osteoblast replication, the induction of osteoblastogenesis, and the inhibition of osteoblast and osteocyte apoptosis by increasing the levels of b-catenin and altering gene expression through the Lef/Tcf transcription factors (Krishnan et al, 2006). The human LRP5 gene is located on chromosome 11q13.4, which consists of 22 introns and 23 exons and spans approximately 160 kb (Smith et al, 2005). Recently, a number of polymorphisms have been described in the LRP5 gene (http://www.ncbi.nlm.nih.gov/SNP).…”

Section: Introductionmentioning

confidence: 99%

Association of LRP5 Ala1330Val polymorphism with fracture risk: a meta-analysis

Peng

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Numerous studies have evaluated the association between the Ala1330Val polymorphism of the low-density lipoprotein receptor-related proteins 5 (LRP5) gene and fracture risk. However, the specific association is still controversial. The aim of this study was to investigate their correlation via metaanalysis. and EMBASE databases were searched, and data were extracted independently by two reviewers. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the associations. Statistical analysis was performed using the STATA 12.0 software. Seven studies, involving 808 cases and 1586 controls, were included in the analysis. Meta-analysis results showed no significant association between the LRP5 Ala1330Val polymorphism and fracture risk (ValVal vs AlaAla: OR = 1.25, 95%CI = 0.82-1.91; AlaVal vs AlaAla: OR = 1.16, 95%CI = 0.95-1.42; dominant model: OR = 1.77, 95%CI = 0.96-1.41; recessive model: OR = 1.21, 95%CI = 0.80-1.83). Taking into account the effect of ethnicity, the LRP5 Ala1330Val polymorphism was not associated with the risk of fracture in Asians or Caucasians. The results of the current meta-analysis indicate that the LRP5 Ala1330Val polymorphism may not be correlated with fracture susceptibility.

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Section: Introductionmentioning

confidence: 99%

Association of LRP5 Ala1330Val polymorphism with fracture risk: a meta-analysis

Peng

et al. 2016

Genet. Mol. Res.

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“…Thus, it has been suggested that the Wnt pathway may represent a "bone and joint connection" [7]. On the other hand, an association between certain polymorphisms of Wnt-related genes and the risk of OA has been reported [11][12][13][14][15][16]. Those data prompted us to study the expression of an array of Wnt pathway genes in the bone tissue of patients with osteoporotic fractures and OA and to explore the possible differences in the allelic frequencies of a SNP set capturing the common variations of Wnt receptors and inhibitors in both skeletal disorders.…”

Section: Introductionmentioning

confidence: 99%

Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study

et al. 2009

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“…In a large meta-analysis, a weak association in a SNP to hip OA was found (OR = 1.12; p <0.016), but not with other OA sites (Evangelou et al, 2009). Another gene of the Wnt signaling pathway, LRP5, has also been associated with OA (Smith et al, 2005), although the results were unable to be replicated in a large population-based study (Kerkhof et al, 2008).…”

Section: Wnt Signaling Pathwaymentioning

confidence: 96%