Haplotyping of STR cluster DXS6801–DXS6809–DXS6789 on Xq21 provides a powerful tool for kinship testing

Szibor, R.; Hering, Sandra; Kuhlisch, Eberhard; Plate, Ines; Demberger, Susanne; Krawczak, Michael; Edelmann, Jeanett

doi:10.1007/s00414-005-0550-z

Cited by 104 publications

(87 citation statements)

References 15 publications

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“…Although the STR combination in group 6 spans distances of as much as 140 kb, no significant linkage disequilibrium was observed in the present Japanese samples. The trio STR clusters of DXS6801-DXS6809-DXS6789, DXS10079-DXS10074-1DXS10075, DXS10146-DXS10134-DXS10147, DXS10148-DXS10135-DXS8378, and DXS10103-HPRTB-DXS10101 have been proposed as haplotypes [1][2][3][4]6]. These STRs were studied further in other populations [7][8][9].…”

Section: Linkage Equilibrium Analysismentioning

confidence: 99%

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Population genetic study of six closely linked groups of X-STRs in a Japanese population

2011

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X chromosome STR (X-STR) polymorphisms are a useful tool in the fields of human population genetics and personal identification and are quite informative in the investigation of complex kinship or deficiency cases, especially where it is necessary to determine relationships with second-generation offspring in which the same X chromosome may have been inherited. We investigated eight X-STR systems using the Mentype Argus X-8 kit and further developed decaplex PCR for the DXS10148, DXS10161, DXS10160, DXS10159, DXS10079, DXS10075, DXS6799, DXS10102, DXS10106, and DXS10146 loci with the aim of constructing closely linked groups on the X chromosome. The studied population comprised 569 Japanese individuals (390 males and 179 females). Heterozygosity among the present 18 X-STRs showed a distribution of from 54.2% to 90.5%. We constructed six closely linked groups, each comprising three to five X-STRs: DXS10148-DXS10135-DXS8378, DXS10161-DXS10160-DXS10159, DXS7132-DXS10079-DXS10074-DXS10075-DXS981, DXS6809-DXS6789-DXS6799, DXS10102-HPRTB-DXS10101-DXS10106, and DXS8377-DXS10146-DXS10134-DXS7423. The forensic utility of these groups as haplotypes was then evaluated. Haplotype diversity values showed a distribution of from 0.9699 to 0.9959. Analysis of the present closely linked haplotypes will contribute to solving complex kinship cases involving X chromosome inheritance.

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Section: Linkage Equilibrium Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Population genetic study of six closely linked groups of X-STRs in a Japanese population

2011

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“…The human X chromosome has been the focus of much research in the fields of population genetics and forensics in recent years, and closely linked groups of markers are becoming more attractive [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. X-chromosomal short tandem repeats (X-STRs) can be used to complement autosomal STRs in paternity testing in female children.…”

Section: Introductionmentioning

confidence: 99%

Genetic study of 12 X-STRs in Malay population living in and around Kuala Lumpur using Investigator Argus X-12 kit

et al. 2012

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We investigated 12 X-chromosomal short tandem repeat (STR) polymorphisms in 283 unrelated Malay individuals (160 males and 123 females) living in and around Kuala Lumpur using the Investigator Argus X-12 kit. Heterozygosity among the present 12 X-STRs showed a distribution of from 55.3 to 93.5 %. The diversity values of the haplotypes constructed using four closely linked groups were all higher than 0.9865. A comparison of allelic frequency in each system and haplotype variation indicated that the nature of these X-STRs in the Malay population differed from that in East Asian, European, or African populations. Several microvariant alleles found in the Malay population were characterized and compared with known sequence data. The present data may be helpful in forensic casework such as personal identification and kinship testing in the Malay population in Malaysia.

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“…These clusters were listed as follows: DXS10135-DXS8378-DXS10148, DXS7132-DXS10074-DXS 10075-DXS10079, DXS10103-DXS10101-HPRTB, DXS10134-DXS7423, DXS10159-DXS10162-DXS 10164, DXS6809-DXS6789, and DXS7424-DXS101. The first four clusters were obtained from a database (http://xdb.qualitype.de/xdb/linkageTable.jsf), and the remaining clusters from previous studies (Edelmann et al, 2002;Szibor et al, 2005). Haplotype frequencies for the seven clusters in 94 male samples are displayed in the Table S1.…”

Section: Haplotype Diversitiesmentioning

confidence: 99%

Genetic polymorphism analyses of a novel panel of 19 X-STR loci in the Chinese Uygur ethnic minority

Guo

Chen

Wang

et al. 2016

J. Zhejiang Univ. Sci. B

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Abstract:The population genetic data and forensic parameters of 19 X-chromosome short tandem repeat (X-STR) loci in Chinese Uygur ethnic minority are presented. These loci were detected in a sample of 233 (94 males and 139 females) unrelated healthy individuals. We observed 238 alleles at the 19 X-STR loci, with the corresponding gene frequencies spanning the range from 0.0021 to 0.5644. After Bonferroni correction (P>0.0026), there were no significant deviations from Hardy-Weinberg equilibrium. The cumulative power of discrimination in females and males, and the probability of exclusion of the 19 X-STR loci were 0. 999 999 999 999 999 999 998

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Haplotyping of STR cluster DXS6801–DXS6809–DXS6789 on Xq21 provides a powerful tool for kinship testing

Cited by 104 publications

References 15 publications

Population genetic study of six closely linked groups of X-STRs in a Japanese population

Population genetic study of six closely linked groups of X-STRs in a Japanese population

Genetic study of 12 X-STRs in Malay population living in and around Kuala Lumpur using Investigator Argus X-12 kit

Genetic polymorphism analyses of a novel panel of 19 X-STR loci in the Chinese Uygur ethnic minority

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