The past decades have seen the rapid development of tactile sensors in material, fabrication, and mechanical structure design. The advancement of tactile sensors has heightened the expectation of sensor functions, and thus put forward a higher demand for data processing. However, conventional analysis techniques have not kept pace with the tactile sensor development and still suffer from some severe drawbacks, like cumbersome models, poor efficiency, and expensive costs. Machine learning, with its prominent ability for big data analysis and fast processing speed, can offer many possibilities for tactile data analysis. Herein, the machine learning techniques employed for processing tactile signals are reviewed. Supervised learning and unsupervised learning for analog signals are covered, and processing spike signals with machine learning are summarized. Furthermore, the applications in robotic tactile perception and human activity monitoring are presented. Finally, the current challenges and future prospects in sensors, data, algorithms, and benchmarks are discussed.