Haptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipients

Abstract

Background. Cardiovascular disease is the leading cause of death in renal transplant recipients (RTRs). An association between haptoglobin genotype 2-2 and cardiovascular disease has been found in patients with diabetes mellitus and liver transplant recipients. To date, the role of haptoglobin genotype after renal transplantation has not been studied. Methods.In this single centre retrospective cohort study of 1975 adult Norwegian RTRs, transplanted between 1999 and 2011, we estimated the risk of all-cause and cardiovascular mortality and overall and death censored graft loss for patients with haptoglobin genotype 2-2 compared with genotype 2-1 or 1-1, after adjustment for confounders and competing risks. Results.We found no associations between haptoglobin genotype 2-2 and cardiovascular mortality (subdistributional hazard ratio [SHR] 1.08, 95% confidence interval [CI] 0.78-1.49, p=0.63). We also failed to detect any association between haptoglobin 2-2 genotype and all-cause mortality, overall graft loss and death censored graft loss. Similar results were found in the subpopulation of diabetic RTRs. Conclusion.In this large cohort of kidney transplant recipients, we could not demonstrate any association between haptoglobin 2-2 genotype and patient or graft survival after renal transplantation.