Haptoglobin and transferrin variation in humans and primates: two new transferrins in Chinese and Japanese populations

Abstract

Summary1. Haptoglobin and transferrin gene frequencies have been determined for Chinese, Japanese, New York City Negro, Sapelo Negro, and Eskimo populations.2. A genetically determined transferrin variant DChi was observed in 6 % of the individuals in the Chinese population. This previously undescribed transferrin migrated slightly more rapidly in starch gel electrophoresis than the transferrin D1 of New York City Negroes.3. A new transferrin variant B3 was observed in a Japanese family. The mobility of this transferrin was slightly slower than the transferrin B2 of Caucasian populations.4. In many instances particular human transferrin variants appear to be restricted to particular populations. The variants which occur in Navajo Indian, Chinese, and Negro populations are discussed in terms of balanced polymorphism.5. Examination of primate sera revealed four different molecular species of chimpanzee transferrin and eight molecular species of rhesus transferrin. All of the rhesus transferrins were more rapidly migrating than human transferrin C, and all of the chimpanzee transferrins migrated more slowly than the human type C. The gene frequencies of several of the primate transferrins are relatively high, whereas of the twelve human variants, only transferrin C is common.6. The distribution of the haptoglobin‐1 allele in world populations shows a progressive East‐West increase from a low value of 0.18 in India to high values of 0.75 in South America and 0.80 in Africa. On the basis of haptoglobin gene frequencies, the proportion of non‐Negro ancestry in several U.S. Negro populations is approximately 40%; the calculated admixture is considerably greater than that estimated from other traits.7. Sera from eight primate species revealed only a single intense haptoglobin band which migrated in the region of the human haptoglobin‐1 band. In addition, faint slower‐moving bands were frequently observed in the primate sera, and were occasionally seen in human Hpl‐1 sera.Chinese sera were collected with the generous assistance of Drs William Ling, Saul Meltzer, Richard Quan, and Trude Schiff. We are greatly indebted to Dr Schiff for obtaining samples from the Chinese CDChi pedigree. Japanese sera were kindly collected by Dr Susumu Shibata, Yamaguchi Medical College, Ube, Japan. We are particularly indebted to Dr Shibata for obtaining sera from the two sons of the individual of transferrin phenotype B3C. Eskimo sera were obtained with the kind cooperation of Dr A. R. Armstrong and Dr E. R. Warburton, Hamilton Health Association, Hamilton, Ontario. We also wish to acknowledge the kind assistance of Dr James Hirsch in obtaining New York City Negro sera and Dr Curtis Hames in obtaining the Sapelo Negro samples. Sera from individuals of transferrin types B2C, BXC, and B0C were kindly provided by Dr E. R. Giblett, King County Central Blood Bank, Inc., Seattle, Washington. All rhesus sera, and the majority of chimpanzee and other primate sera were kindly provided by Dr Morris Goodman and Dr Emily Poulik, Wayne State University, Detroit, Michigan. We are also indebted to the Yerkes Laboratories of Primate Biology, Orange Park, Florida, for chimpanzee sera, and to Dr J. Buettner‐Janusch, Yale University, New Haven, Connecticut, for cercopithecus and baboon sera. These investigations were aided by a grant from The National Foundation, and by a grant from the Public Health Service (A‐1542 (C2)).

“Private” Genetic Variants and the Frequency of Mutation Among South American Indians

“…17.8% of the Piaroa Indians we studied; a variant with similar mobility was observed in 58% of 91 Yupa Indians from the extreme west of Venezuela (19). The original demonstration of a variant with this mobility was in people of Chinese extraction (Kwantung Province, southern China) residing in New York City (20). It is impossible to state at present whether these are identical variants.…”

Electrophoretic variants of blood proteins in Japanese VI. Transferrin

“…In Japanese populations, Parker and Bearn (1961), Matsumoto (1964), Omoto and Harada (1972), and Kirk et al (1978) have reported rare electrophoretic variants. Ferrell et al (1977), examining 4,029 Japanese residing in Hiroshima and Nagasaki, reported three types of B-variant and five types of D-variant.…”

Transferrin variants in Korea and Japan

“…The B1 variant was first described in England by Harris et al (1958) and the identification of the Japanese variants as B1 is almost certainly incorrect, a point which will be discussed in greater detail below. The B3 had been described in a Japanese from Ube by Parker and Bearn (1961).…”