Haptoglobin concentration in galgos and greyhounds

Zaldívar‐López, Sara; Mesa-Sánchez, Ignacio; Galan-Rodriguez, A.; Cerón, José J.; Martı́nez-Subiela, Silvia; Granados-Machuca, M. M.; Couto, C. Guillermo

doi:10.1136/vr.100411

Cited by 3 publications

(3 citation statements)

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“…Previous studies have shown that Galgos have similar haematological values than those found in Greyhounds (MesaSanchez et al 2012); however, they have different electrolyte concentrations, blood gas values, acid-base balance and prevalence of dog erithrocyte antigen 1.1, compared with those previously described in Greyhounds (Mesa-Sanchez et al 2012, 2014. Interestingly, Galgos also have slightly higher haptoglobin concentration than the general population of dogs, in contrast to Greyhounds, which have undetectable haptoglobin levels (Zaldívar-López et al 2012). As Galgos have higher haptoglobin than Greyhounds and other breeds, and this protein migrates in the α-globulin fraction, the authors hypothesised that Galgos have breed-specific differences in serum protein electrophoresis, but these differences are not necessarily the same previously described in Greyhounds.…”

Section: Introductionmentioning

confidence: 79%

“…A low α2-globulin concentration has also been described in Greyhounds (Fayos et al 2005), and a low concentration of haptoglobin has been proposed to explain this feature in this breed (Couto et al 2009). However, a recent study showed that Galgos have slightly higher haptoglobin concentration than the general population of dogs, in contrast to Greyhounds, which have undetectable haptoglobin levels (Zaldívar-López et al 2012). Therefore, further studies in Galgos are necessary to identify the individual proteins associated with the loprotein w α2-globulin concentration, and its clinical significance.…”

Section: Discussionmentioning

confidence: 96%

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Serum protein electrophoresis in Galgos

et al. 2015

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The Galgo is a member of the sighthound family and is one of the most popular breeds in Spain. Several sighthound breeds have laboratory values that are outside the reference intervals established for the general population of dogs. Serum protein electrophoresis has not been studied in Galgos and they are often interpreted as if they were Greyhounds. However, recent studies suggest that each sighthound breed presents its own specific laboratory features, and the extrapolation of the information described in Greyhounds to other sighthound breeds could lead to misdiagnoses. The aims of this study were as follows: (1) to evaluate the results of serum protein electrophoresis in healthy Galgos and compare them with a control group of age-and gender-matched dogs of other breeds and (2) to determine if serum protein electrophoresis profiles in Galgos are similar to those previously reported in Greyhounds. Serum protein electrophoresis using agarose gel was measured in 30 healthy Galgos and 22 age-and gender-matched control dogs of other breeds to assess any differences. Galgos had higher albumin, β-globulins and albumin to globulin ratio and lower total globulins, α2-globulins and γ-globulins, than those in the control group. These data confirm that Galgos have breedspecific features in serum protein electrophoresis and that those values previously described in Greyhounds should not be extrapolated to Galgos. The knowledge of these breedspecific differences will help avoid misdiagnoses when interpreting serum protein electrophoresis in Galgos.

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Section: Introductionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 96%

Serum protein electrophoresis in Galgos

et al. 2015

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“…Pelo fato das outras proteínas de fase aguda em cachorro-do-mato, cães domésticos e humanos terem o mesmo comportamento, entendemos que esta correlação clínica para a transtirretina possa ser utilizada, entretanto, se torna necessário maiores estudos. Ceron, et al (2005) e Zaldívar-López, et al(2014) relatam que a concentração de haptoglobina pode ser utilizada como diangóstico e prognóstico em vários processos inflamatórios. Segundo os autores, a resposta ao seu estímulo pode variar de duas a dez vezes sua concentração no plasma após 24 horas e permanecer por tres a quatro dias.…”

Section: (Gráfico Iv)unclassified

Determinação das principais proteínas de fase aguda e do índice prognóstico inflamatório nutricional (IPIN) em cachorro-do-mato (Cerdocyon thous - Linnaeus, 1766)

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AGRADECIMENTOS Agradeço ao meu orientador Prof. Dr. André Luiz Quagliatto Santos pela oportunidade de compartilhar seu conhecimento e dedicação. A Universidade Federal de Uberlândia que me recebeu durante o mestrado e doutorado. Aos professores da pós graduação da UFU que contribuíram para a minha formação, aos colegas Thais Carneiro, Liliane Rangel e Evandro Canelo e aos funcionários do LAPAS-UFU. A Paula de Oliveira Braga pela paciência, compreensão e amor.

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