Haptoglobin expression and release by rabbit oviduct and endometrium, its localization in blastocyst extra-embryonic matrix and fluid during preimplantation time

Herrler, Andreas; Krusche, Claudia A.; Müller-Schöttle, Frank; Beier, Henning M.

doi:10.1093/humrep/deh517

Cited by 14 publications

(19 citation statements)

References 23 publications

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“…In addition to potential roles in scavenging, binding of hemoglobin-haptoglobin complexes to CD163 is suggested to play immunomodulatory roles by increasing the expression of heme oxygenases and secretion of IL-6 and IL-10. 50 The function of haptoglobin in bovine ovary and oviduct and rabbit oviduct and endometrium, where it was found in blastocyst extraembryonic matrix, is unknown 51,52 It is noteworthy that MMP-9 is also thought to be involved in implantation and trophoblast function. Physiologic roles of soluble forms of CD163, which are capable of binding hemoglobin-haptoglobin complexes and have plasma concentrations that increase manyfold during reactive hemophagocytic syndrome, sepsis, and some other conditions, is not yet understood.…”

Section: Discussionmentioning

confidence: 99%

Biochemical and enzymatic characterization of purified covalent complexes of matrix metalloproteinase-9 and haptoglobin released by bovine granulocytes in vitro

Bannikov¹,

Mattoon²,

Abrahamsen³

et al. 2007

ajvr

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Section: Discussionmentioning

confidence: 99%

Biochemical and enzymatic characterization of purified covalent complexes of matrix metalloproteinase-9 and haptoglobin released by bovine granulocytes in vitro

Bannikov¹,

Mattoon²,

Abrahamsen³

et al. 2007

ajvr

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“…Haptoglobin has been identified previously in cow and rabbit oviductal fluid. In rabbits, the highest expression of mRNA was detected at the time of ovulation (73). The extraembryonic matrix of preimplantation embryos and blastocyst fluid were found to contain haptoglobin, although the embryo itself does not express haptoglobin.…”

Section: And 2) and Identified By Lc-esi-ms/msmentioning

confidence: 97%

Gametes Alter the Oviductal Secretory Proteome

Georgiou

Šoštarić

Wong

et al. 2005

Molecular & Cellular Proteomics

141

143

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The mammalian oviduct provides an optimal environment for the maturation of gametes, fertilization, and early embryonic development. Secretory cells lining the lumen of the mammalian oviduct synthesize and secrete proteins that have been shown to interact with and influence the activities of gametes and embryos. We hypothesized that the presence of gametes in the oviduct alters the oviductal secretory proteomic profile. We used a combination of two-dimensional gel electrophoresis and liquid chromatography-tandem mass spectrometry to identify oviductal protein secretions that were altered in response to the presence of gametes in the oviduct. The oviductal response to spermatozoa was different from its response to oocytes as verified by Western blotting. The presence of spermatozoa or oocytes in the oviduct altered the secretion of specific proteins. Most of these proteins are known to have an influence on gamete maturation, viability, and function, and there is evidence to suggest these proteins may prepare the oviductal environment for arrival of the zygote. Our findings suggest the presence of a gamete recognition system within the oviduct capable of distinguishing between spermatozoa and oocytes. The mammalian oviduct is the venue of important events leading to the establishment of pregnancy. These events include final maturation and transport of the female and male gametes, fertilization, cleavage-stage embryonic development, and transport of the embryo to the uterus. In mammals, the physiological interaction between gametes, embryos, and oviductal epithelia involves intimate and specific contact between the two cell types (1-6). During the estrous or menstrual cycle, the mammalian oviduct undergoes significant endocrine-induced morphological, biochemical, and physiological changes. These changes establish an essential microenvironment within the oviduct. Oviductal fluid is a crucial part of this milieu and consists of transudate from serum together with specific compounds synthesized by the luminal epithelium. The current dogma states that the oviductal environment and the composition of oviductal fluid are solely under the influence of the hormonal changes in the oviduct (7-9). However, in recent years, several investigations from our laboratory and others have challenged this view by providing evidence of transcriptional changes in the oviduct in response to gametes irrespective of oviductal hormonal status (10 -12).Although these data provide strong evidence in relation to the modulation of the oviductal environment by gametes, they lack information regarding changes to the oviductal proteomic profile, for example the secretory profile. In mammals, not all the changes in the transcriptome are translated into proteomic alterations due to post-translational modifications. Ellington et al. (13) and Thomas et al. (14) provide the only evidence that at least spermatozoa can influence the (secretory) proteomic profile of oviductal epithelial cells. These investigations have reported de novo protein synthesis...

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“…Although Hp is believed to be important for implantation and pregnancy, it’s functional role is not known [11]. Increases in Hp concentration in the rabbit oviduct and uterus follow the time-course of blastocyst transit, and the blastocyst incorporates maternal Hp into its extra-embryonic matrix [11].…”

Section: Discussionmentioning

confidence: 99%

“…Increases in Hp concentration in the rabbit oviduct and uterus follow the time-course of blastocyst transit, and the blastocyst incorporates maternal Hp into its extra-embryonic matrix [11]. Phenotype effects cannot be examined in the rabbit, as this species only has the Hp 1-1 phenotype [26].…”

Section: Discussionmentioning

confidence: 99%

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Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort

Weissgerber

McGee

Myatt

et al. 2014

The Journal of Maternal-Fetal & Neonatal Medicine

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Objective The anti-oxidant and proangiogenic protein haptoglobin (Hp) is believed to be important for implantation and pregnancy, although its specific role is not known. The three phenotypes (1-1, 2-1 and 2-2) differ in structure and function. Hp 2-2 is associated with increased vascular stiffness in other populations. We examined whether Hp phenotype is associated with abnormal uterine artery Doppler (UAD) in pregnancy. Methods We conducted a secondary analysis of a preeclampsia prediction cohort nested within a larger placebo-controlled randomized clinical trial of antioxidants for prevention of preeclampsia. We determined Hp phenotype in 2,184 women who completed UAD assessments at 17 weeks gestation. Women with notching were re-evaluated for persistent notching at 24 weeks gestation. Logistic regression was used to assess differences in UAD indices between phenotype groups. Results Hp phenotype did not significantly influence the odds of having any notch (p=0.32), bilateral notches (p=0.72), or a resistance index (p = 0.28) or pulsatility index (p = 0.67) above the 90th percentile at 17 weeks gestation. Hp phenotype also did not influence the odds of persistent notching at 24 weeks (p=0.25). Conclusions Hp phenotype is not associated with abnormal UAD at 17 weeks gestation or with persistent notching at 24 weeks.

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Haptoglobin expression and release by rabbit oviduct and endometrium, its localization in blastocyst extra-embryonic matrix and fluid during preimplantation time

Cited by 14 publications

References 23 publications

Biochemical and enzymatic characterization of purified covalent complexes of matrix metalloproteinase-9 and haptoglobin released by bovine granulocytes in vitro

Biochemical and enzymatic characterization of purified covalent complexes of matrix metalloproteinase-9 and haptoglobin released by bovine granulocytes in vitro

Gametes Alter the Oviductal Secretory Proteome

Haptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort

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