Haptoglobin gene polymorphism in type 2 diabetic patients with and without nephropathy: An Egyptian study

Bessa, Sahar Saad El-Din; Hamdy, Soha M.; Ali, Ehab M.M.

doi:10.1016/j.ejim.2007.02.033

Cited by 23 publications

(17 citation statements)

References 46 publications

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“…Nakhoul et al (2000) found that the Hp2-2 phenotype is overrepresented in Israeli type 1 DM patients with diabetic retinopathy, while type 1 and type 2 DM patients with the Hp1-1 phenotype had greater protection against diabetic nephropathy (Nakhoul et al, 2001). Similar findings were reported by Bessa et al (2007) for Egyptian patients with type 2 DM. Koda et al (2002), however, failed to detect a protective effect that could be attributed to the HP1 allele in Japanese type 2 DM patients.…”

Section: Hp Polymorphism and Diseasessupporting

confidence: 62%

Polymorphism of human haptoglobin and its clinical importance

2008

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Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders.

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Section: Hp Polymorphism and Diseasessupporting

confidence: 62%

Polymorphism of human haptoglobin and its clinical importance

2008

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“…We examined the association of DN and the Hp polymorphism and found that the Hp 1-1 genotype was associated with a significantly lower prevalence of DN (22,34) and an apparent slower rate of progression of DN to ESRD (9, 13) compared with individuals with Hp 2-1 and Hp 2-2. These findings have recently been confirmed by three independent groups in independent cohorts (4,5,12).…”

supporting

confidence: 59%

Pharmacogenomic effect of vitamin E on kidney structure and function in transgenic mice with the haptoglobin 2-2 genotype and diabetes mellitus

Nakhoul

Miller‐Lotan²,

Awad³

et al. 2009

American Journal of Physiology-Renal Physiology

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“…Hp has been known to be a major susceptibility gene in diabetic vascular complications in humans (Asleh and Levy 2005). Different alleles of Hp in humans are thought to have different antioxidant efficiencies, resulting in different susceptibilities to diabetic nephropathy, retinopathy, and cardiovascular disease (Bessa et al 2007;Nakhoul et al 2007). Increased inflammation is associated with aging (Ferrucci et al 2005).…”

Section: Hpmentioning

confidence: 99%

Plasma biomarkers of mouse aging

Ding

Kopchick

2010

AGE

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Normal aging is accompanied by a series of physiological changes such as gray hair, cataracts, reduced immunity, and increased susceptibility to disease. To identify novel biomarkers of normal aging, we analyzed plasma proteins of male mice longitudinally from 2 to 19 months of age. Plasma proteins were analyzed by two-dimensional gel electrophoresis and identified using mass spectrometry (MS), MS/MS and liquid chromatography MS/MS. We found that many plasma proteins exist as multiple isoforms with different masses and/or charges. Thirty-nine protein spots (corresponding to six distinct proteins) have been identified, 13 of which exhibited significant changes with age. For example, several proteins increased significantly during aging including one isoform of transthyretin, two isoforms of haptoglobin, and three isoforms of immunoglobulin kappa chain. Conversely, several proteins decreased significantly during aging including peroxiredoxin-2, serum amyloid protein A-1, and five isoforms of albumin. Identification of these proteins provides new biomarkers of normal aging in mice. If validated in humans, these biomarkers may facilitate therapeutic interventions to identify premature aging, delay aging, and/or improve healthspan of the elderly.

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Haptoglobin gene polymorphism in type 2 diabetic patients with and without nephropathy: An Egyptian study

Cited by 23 publications

References 46 publications

Polymorphism of human haptoglobin and its clinical importance

Polymorphism of human haptoglobin and its clinical importance

Pharmacogenomic effect of vitamin E on kidney structure and function in transgenic mice with the haptoglobin 2-2 genotype and diabetes mellitus

Plasma biomarkers of mouse aging

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