Haptoglobin Groups and Cirrhosis of the Liver

Zhao, Haijiao; Zhang, Guiyin

doi:10.1159/000154131

Cited by 8 publications

(4 citation statements)

References 3 publications

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“…In this study a significant increase in the frequency of Hp1-1 phenotype was observed among patients with all three liver diseases including liver cirrhosis which agrees with (Blenk et al, 1978;Zhao et al, 1993), but disagreed with (Vitalis et al, 2011). Therefore, it is reasonable to conclude that individuals with Hp1-1 phenotypes might be more susceptable to liver cancer than individuals with other Hp phenptypes however, this needs more confirmation at the molecular and immunological levels…”

Section: Discussionsupporting

confidence: 85%

“…found that people with Hp1-1 phenotype are more susceptible to falciparum malaria and to development of severe complications, the same phenotype was also associated with other different liver diseases such as those with liver cirrhosis who showed a significant difference from controls in the distribution of Hp types, with increases in the Hp*1 allele and Hp1-1 phenotype frequencies (Zhao et al, 1993).…”

Section: Introductionmentioning

confidence: 94%

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Association of Hp 1-1 with liver disorders among Sudanese patients

Ibrahim¹,

Baleela²

2012

AJSIR

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An assessment study was conducted to investigate the role of serum Haptoglobin (Hp) phenotypes in Sudanese patients with liver diseases on susceptibility to attain these diseases. Hp phenotypes were determined by separating sera supplemented with haemolysate on 4.7% polyacrylamide gel electrophoresis followed by Benzidine staining. The number of individuals with Hp1-1 was found significantly higher among patients with hepatitis B virus infection (HBV) (P<0.0005), patients with liver cirrhosis (P<0.0005) and patients with liver cancer (P<0.002) when compared to healthy control group. We suggest an association between Hp1-1 and susceptibility to HBV, liver cirrhosis and liver cancer that might be further associated with the development of different pathological complications.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 94%

Association of Hp 1-1 with liver disorders among Sudanese patients

Ibrahim¹,

Baleela²

2012

AJSIR

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“…et al, 2000) and type II (Nakhoul et al, 2001) diabetes. Zhao and Zhang (1993) found that Hp1‐1 was over‐represented in 107 patients with cirrhosis of the liver compared with 552 normal adults (relative risk 3·3, P = 2 × 10 −4 ). Zipprich et al (1986) found an increased frequency of Hp1‐1 in 100 German patients with chronic, non‐alcoholic liver disease but not in 90 patients with cirrhosis when compared with 1726 control subjects.…”

Section: Discussionmentioning

confidence: 99%

Haptoglobin type neither influences iron accumulation in normal subjects nor predicts clinical presentation in HFE C282Y haemochromatosis: phenotype and genotype analysis

et al. 2003

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Summary. In the UK, 90% of patients with hereditary haemochromatosis (HH) are homozygous for HFE C282Y, as are one in 150 people in the general population. However, only a minority of these will develop clinical haemochromatosis. Iron loss modifies iron accumulation but so may other genetic factors. Haptoglobin (Hp) exists as three major types (Hp 1-1, Hp 2-1 or Hp 2-2) and binds free plasma haemoglobin. In men, Hp 2-2 has been shown to be associated with increased macrophage iron accumulation and serum ferritin concentration. Furthermore, the frequency of Hp 2-2 was shown to be increased in patients with HH. We determined Hp types by phenotyping and genotyping 265 blood donor control subjects and 173 subjects who were homozygous for HFE C282Y. The latter group included 66 blood donors lacking clinical features suggestive of haemochromatosis and without a known family history, and 68 patients presenting clinically with haemochromatosis. Hp 2-2 frequencies did not differ in control subjects and C282Y homozygotes. Hp 2-2 was not a risk factor for disease development in HH. To investigate the relationship between iron accumulation and haptoglobin type, we determined transferrin saturation and serum ferritin concentration in 192 male, first-time blood donors aged 20-40 years who lacked both HFE C282Y and H63D. Transferrin saturation and serum ferritin concentrations did not vary with Hp type.

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“…6,8,32,40 As previously reported, several studies have demonstrated that Hp phenotypes play a role in sparing Hb. 27,[50][51][52] This protein expresses three phenotypes with different affinities to bind to Hb. Hp 1.1 has a higher Hb-binding ability than the 2.2 and 2.1 phenotypes and limits Hb elimination by the liver.…”

Section: Discussionmentioning

confidence: 99%

Iron metabolism markers and haptoglobin phenotypes in susceptibility to HSV‐1 or/and HSV‐2 lesion relapses

Gennero

Roos

Denysenko

et al. 2010

Cell Biochemistry & Function

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Different haptoglobin (Hp) phenotypes play a role in several pathologic processes including infectious diseases. In order to evaluate the role of iron storage and metabolism in susceptibility to herpetic manifestations, we studied the frequency of the Hp phenotypes and iron metabolism in patients affected by H. Simplex virus 1 or 2 (HSV-1 or HSV-2), compared with controls. Hp phenotype and iron metabolism were determined in 100 patients with recurrent HSV-1 or HSV-2 manifestations during the relapses, and in 110 healthy subjects. The frequencies of the three Hp phenotypes in the patient group compared to the control group were 18% versus 14.5% p = NS for Hp 1.1, 25% versus 40% p = 0.03 for Hp 2.2 and 57% versus 45.5% p = NS for Hp 2.1. All iron metabolism parameters tested showed significant differences between patients and controls; haemoglobin (Hb), ferritin, and serum iron were lower, while transferrin was higher in the patients than in controls. Reductions in iron availability may be a risk factor for relapsing lesions of HSV-1 or HSV-2. Hp 2.2 phenotype may offer some protection against the recurrence of Herpes labialis or genitalis manifestations.

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Haptoglobin Groups and Cirrhosis of the Liver

Cited by 8 publications

References 3 publications

Association of Hp 1-1 with liver disorders among Sudanese patients

Association of Hp 1-1 with liver disorders among Sudanese patients

Haptoglobin type neither influences iron accumulation in normal subjects nor predicts clinical presentation in HFE C282Y haemochromatosis: phenotype and genotype analysis

Iron metabolism markers and haptoglobin phenotypes in susceptibility to HSV‐1 or/and HSV‐2 lesion relapses

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