Haptoglobin is an Exercise-Responsive Acute-Phase Protein

Chen, Cheng-Yu; Hsieh, Wan-Ling; Lin, Po‐Ju; Chen, Yung-Liang; Mao, Simon J.T.

doi:10.5772/21827

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…Haptoglobin may increase after acute exercise training in humans and after long-term exercise in mice. 29 The absence of any changes of the HPHDL in our population may express a low inflammation status in the absence of an established macrovascular disease or diabetes. Only two out of 62 patients of the current trial had diabetes and coronary artery disease.…”

Section: Discussionmentioning

confidence: 83%

The impact of aerobic and isometric exercise on different measures of dysfunctional high-density lipoprotein in patients with hypertension

Pagonas

Vlatsas

Bauer

et al. 2019

Eur J Prev Cardiolog

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Background: Exercise training increases high-density lipoprotein (HDL) cholesterol, but its effect on HDL function is unclear. In hypertensives, exercise improves endothelial dysfunction, which is related to HDL function. In the present study, we assess for the first time the effects of different exercise modalities on two cell-free assays of HDL function. Design: The study was conducted as a prospective randomized controlled trial in 75 hypertensive patients. Methods: Patients were randomized in three groups: (a) handgrip isometric training five times weekly; (b) placebo-handgrip; and (c) aerobic exercise training at least three times per week. HDL function was assessed in serum samples at baseline and after 12 weeks of training by two independent assays that determine the proinflammatory phenotype (haptoglobin content) of a specific amount of HDL (Haptoglobin-HDL [HPHDL]) and oxidized HDL (HDLox) as a measure of reduced antioxidant function of HDL. HDL function measures were normalized by the measures of a pooled control of sera from healthy participants and by HDL-C levels (normalized ratio, no units). Results: Aerobic exercise led to significant reduction of the HDLox from 0.99 ± 0.27 to 0.90 ± 0.29 (no units, p = 0.03). The HPHDL did not change in any training group. Changes of HDLox correlated with reduction of the systolic blood pressure only after aerobic exercise (R = 0.64, p = 0.03). Conclusions: Aerobic but not isometric exercise improves the antioxidant function of HDL in patients with hypertension. This improvement correlates positively with reductions of blood pressure.

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Section: Discussionmentioning

confidence: 83%

The impact of aerobic and isometric exercise on different measures of dysfunctional high-density lipoprotein in patients with hypertension

Pagonas

Vlatsas

Bauer

et al. 2019

Eur J Prev Cardiolog

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“…In another study, we showed that one short-term jogging and explosive run are able to induce a substantial elevation of Hp in peripheral blood. In mice, Hp levels are elevated significantly and concomitantly with the increase in neutrophils over the circulation following a 2-week exercise [19]. This finding not only suggests that acute net increase in Hp levels may be directly derived from the neutrophils but also indicates that Hp could be a biomarker for the neutrophil functional activity.…”

Section: Clinical Significance Of Hp Phenotypesmentioning

confidence: 84%

Unique Assembly Structure Of Human Haptoglobin Phenotypes 1-1, 2-1, And 2-2 And A Predominant Hp1 Allele Hypothesis

Cheng¹,

Larsson

Chiang³

et al. 2009

Biophysical Journal

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“…The changes in haptoglobin levels can be caused by the fact that exercise induces a chronic hemolytic reaction [ 67 ]. Nevertheless, there still are ongoing controversial debates about the effect of exercise on haptoglobin expression; however, it is noteworthy that in general, the increase in haptoglobin expression in response to exercise occurs rather slowly and is observed 5 days after a single exercise session [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolomic and Proteomic Profiling of Athletes Performing Physical Activity under Hypoxic Conditions

Malsagova,

Kopylov,

Stepanov

et al. 2024

Sports

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Proteomic and metabolomic research enables quantitation of the molecular profile of athletes. Multiomic profiling was conducted using plasma samples collected from 18 male athletes performing aerobic activity (running) at high altitude. Metabolomic profiling detected changes in the levels of 4-hydroxyproline, methionine, oxaloacetate, and tyrosine during the recovery period. Furthermore, proteomic profiling revealed changes in expression of proteins contributing to the function of the immune system, muscle damage, metabolic fitness and performance, as well as hemostasis. Further research should focus on developing metabolic models to monitor training intensity and athlete adaptation.

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Haptoglobin is an Exercise-Responsive Acute-Phase Protein

Cited by 6 publications

References 32 publications

The impact of aerobic and isometric exercise on different measures of dysfunctional high-density lipoprotein in patients with hypertension

The impact of aerobic and isometric exercise on different measures of dysfunctional high-density lipoprotein in patients with hypertension

Unique Assembly Structure Of Human Haptoglobin Phenotypes 1-1, 2-1, And 2-2 And A Predominant Hp1 Allele Hypothesis

Metabolomic and Proteomic Profiling of Athletes Performing Physical Activity under Hypoxic Conditions

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