Haptoglobin Phenotypes in Epilepsy

Sadrzadeh, S.M. Hossein; Saffari, Yasi; Bozorgmehr, Jafar

doi:10.1373/clinchem.2003.028001

Cited by 27 publications

(13 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are similar to those found by other authors (Sadrzadeh et al, 2004;Ilzecka, 1996;Al-Balaghee et al, 2015). Indeed, they found a significant relation between the Hp2-2 phenotype and the frequency of seizures.…”

Section: Discussionsupporting

confidence: 93%

Haptoglobin polymorphism and cardiovascular risk factors in followed epileptic patients at Fann National University Hospital

Gueye¹,

Djite²,

Ndour³

et al. 2017

Afr. J. Biochem. Res.

View full text Add to dashboard Cite

The aim of our research was to evaluate the cardiovascular risk factors on epileptic patients treated at the Fann University Hospital and to study the influence of haptoglobin (Hp) polymorphism on disease progression. In order to do that, eighty-six (86) patients followed in neurology for at least 2 years were recruited. Each patient was matched to a control according to age and sex. Hp phenotyping was performed by electrophoresis on polyacrylamide gel, and lipid peroxidation was quantified by the dosage of the thiobarbituric acid reacting substances (TBARS). The determination of a number of biochemical parameters was performed in both patients and controls. The evaluation of lipid parameters showed significant differences in total cholesterol levels, triglycerides, low-density lipoprotein (LDL) cholesterol and atherogenic index between patients and controls. For C-Reactive Protein-ultra sensible (CRP-us) values greater than 3 mg / L, a statistically significant difference was found (p = 0.009). The frequencies of the three major phenotypes of patients compared to controls has shown significant difference only for Hp2-2 phenotype (p = 0.042). The significant increase of TBARS for patients compared to controls suggested an oxidative mechanism. Results have shown a risk of developing cardiovascular diseases during the progression of epilepsy. The influence of Hp polymorphism in modulating oxidative stress suggests that taking antioxidants may have a beneficial effect, especially in patients of phenotype Hp2-2.

show abstract

Section: Discussionsupporting

confidence: 93%

Haptoglobin polymorphism and cardiovascular risk factors in followed epileptic patients at Fann National University Hospital

Gueye¹,

Djite²,

Ndour³

et al. 2017

Afr. J. Biochem. Res.

View full text Add to dashboard Cite

show abstract

“…They declared that Hp 2 (the most common Hp in Asians) leads to instability, low concentration, and higher susceptibility to oxidation of vitamin C. Costa‐Mallen and colleagues concluded that Hp polymorphisms are associated with idiopathic Parkinson's disease in American women . Sadrzadeh et al . determined that Hp 2‐2 significantly ( P < 0.001) increases the risk of recurrent seizures in epilepsy.…”

Section: Discussionmentioning

confidence: 99%

“…atherosclerosis, inflammatory bowel disease, diabetes, celiac disease, Parkinson's disease, recurrent seizures, etc.) are more prevalent in patients carrying the 2.2 genotype . Moreover, Heme is an essential nutrient for some bacteria involved in pathogenesis of periodontitis and peri‐implantitis like Porphyromonas gingivalis and Prevotella intermedia .…”

Section: Introductionmentioning

confidence: 99%

Haptoglobin gene polymorphisms in peri‐implantitis and chronic periodontitis

Ebadian

Kadkhodazadeh

Naghavi

et al. 2013

J of Invest & Clin Dent

View full text Add to dashboard Cite

show abstract

“…In another study looking at the association of haptoglobin phenotypes and the frequency of seizure in patients with refractory epilepsy, Sadrzadeh et al [33] found a significant association between Hp 2-2 phenotypes and the frequency of seizures. That is, 67% of epileptic patients with Hp 2-2 phenotype experienced one or more seizure attacks per month as compared to 11% seen in those with Hp1-1.…”

Section: Discussionmentioning

confidence: 99%

Haptoglobin phenotype and apolipoprotein E polymorphism: Relationship to posttraumatic seizures and neuropsychological functioning after traumatic brain injury

Anderson

Temkin

Dikmen

et al. 2009

Epilepsy & Behavior

View full text Add to dashboard Cite

The relationship between genetic predisposition to reduced iron capacity and apolipoprotein E (APOE) with post-traumatic seizures (PTS) and neuropsychological outcomes was investigated in patients with traumatic brain injuries (TBI) from a prior valproate clinical study. Haptoglobin (Hp) concentration/phenotype and APOE genotype was determined in 25 PTS and 26 controls (no PTS) subjects ~10 year after TBI. Hp phenotype was also determined in previously collected frozen samples for 25 additional PTS and 32 no PTS subjects. There was no relationship between Hp phenotype or APOE genotype and occurrence of PTS. APOE genotype was not related to neuropsychological outcome; however when adjustments were made for differences in educational levels, APOE ε4 subjects did worse especially on verbal intellectual and verbal memory skills. In contrast to our hypothesis, those with Hp 1-1 (high affinity binder of hemoglobin), scored somewhat worse on verbal IQ and Tapping D at 1 and 12 month after injury.

show abstract

Haptoglobin Phenotypes in Epilepsy

Cited by 27 publications

References 24 publications

Haptoglobin polymorphism and cardiovascular risk factors in followed epileptic patients at Fann National University Hospital

Haptoglobin polymorphism and cardiovascular risk factors in followed epileptic patients at Fann National University Hospital

Haptoglobin gene polymorphisms in peri‐implantitis and chronic periodontitis

Haptoglobin phenotype and apolipoprotein E polymorphism: Relationship to posttraumatic seizures and neuropsychological functioning after traumatic brain injury

Contact Info

Product

Resources

About