Haptoglobin Polymorphism in Korean Patients with Cardiovascular Diseases

Hong, Seung Ho; Kang, Byung Yong; Lim, Jaewon; Namkoong, Yong; Oh, Moon You; Kim, Jin Q; Leé, Chung Choo

doi:10.1159/000154425

Cited by 5 publications

(5 citation statements)

References 7 publications

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“…et al investigated the relationship between Hp polymorphism and plasma lipid levels and found that the distribution of Hp phenotypes did not show any significant differences between the healthy controls and the patients with cardiovascular disease. But Hp phenotypes were associated with levels of high-density lipoprotein cholesterol in the hypertensive group [9]. Since that study, there have been several reports have demonstrated the role of cardiovascular events in pathogenicity of AMI.…”

Section: Figure 2 Electrophoretic Pattern Of Different Hp Phenotypesmentioning

confidence: 80%

“…An early study in 1997, examined Hp polymorphism in Korean patients with cardiovascular disease. The results indicated that Hp polymorphism, at least in the Korean population, does not predispose to the occurrence of cardiovascular disease [9] and Hp may Furthermore, a study with the aim of the relationship between Hp type and prevalence of coronary heart disease in a cross-sectional study from a large community-based cohort, the results showed interaction between Hp type and diabetes in the prevalence of coronary heart disease (CHD) [16]. On the other hand study of Hp polymorphism in patients who suffered from diabetes and acute myocardial infarctions showed that this polymorphism was a predictor of 30-day mortality and heart failure [24].…”

Section: Discussionmentioning

confidence: 90%

“…We assumed that inflammation underlies the development and progression of AMI disease and as discussed Hp is an inflammatory marker. Some evidence suggests that the Hp phenotype is associated with the development of cardiovascular events and has a role in induction of AMI pathogenicity [9]. The inflammation mechanisms underlies the development and progression of AMI linking with Hp phenotype frequency have been listed by some researchers.…”

Section: Discussionmentioning

confidence: 99%

“…Diagnostic criteria for AMI is at least two of the following symptoms; severe chest pain more than 20 minutes, changes in ST segment elevation of ECG, increase in cardiac markers including serum creatine phosphokinase (CK), MB creatine kinase (CKMB), cardiac troponin T (CTUT) and troponin I (CTUI) [9]. Recently molecular studies in China, indicated that a new biomarker, lymphocyte-specific protein tyrosine kinase (LCK), can be a candidate for the early diagnosis of AMI [31].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of haptoglobin phenotypes in acute myocardial infarction (AMI) and their association with some risk factors

et al. 2020

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Acute myocardial infarction (AMI) is one of the most common cardiovascular complications with a complex pathogenesis where inflammatory markers are involved in disease etiology. The aim of this Khazaei H.A. et al. Хазеи Х.А. и др. Medical Immunology (Russia)/Meditsinskaya Immunologiya Медицинская Иммунология study was to investigate haptoglobin phenotypes and their association with some risk factors in patients with a history of AMI. 120 patients who were referred to the emergency department of Amir Al Momenin hospital of Zahedan city, Zahedan-Iran were recruited in a cross-sectional case control study. 120 normal individuals were also chosen as controls for this study. Serum was isolated from routine bloods taken for diagnostic tests and used to determine haptoglobin phenotype distribution by electrophoresis. Phenotype differences as percent of phenotype frequency in patient and control groups were analysed using the χ 2 test and SPSS software. A high frequency of serum Hp2-2 haptoglobin phenotype in patients and healthy control were found (62.5% and 58.3% respectively). A meaningful statistical correlation between high frequency of Hp2-2 haptoglobin phenotype and AMI was not found (p value = 0.484). Whereas high frequency of Hp1-1 and HP2-2 phenotypes was associated with hyperlipidemia and hypertension respectively (p value = 0.01 and 0.04). Our results showed that there was a high frequency of Hp2-2 haptoglobin phenotype in patients as well as healthy controls in the population studies. High frequencies of Hp1-1and Hp2-2 phenotypes were associated with AMI in patients with hyperlipidemia and hypertension respectively. Thus these phenotypes in AMI patients may modulate the inflammatory response in combination with hyperlipidemia and hypertension.

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Section: Figure 2 Electrophoretic Pattern Of Different Hp Phenotypesmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of haptoglobin phenotypes in acute myocardial infarction (AMI) and their association with some risk factors

et al. 2020

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“…Another possibility is that the effect of the Hp phenotype on the interindividual difference in the VO 2max index results from linkage disequilibrium between the Hp phenotype and another causative allele. Some studies have suggested linkage disequilibrium as a mechanism for the association between the Hp phenotype and serum lipid levels [38][39][40].…”

Section: Discussionmentioning

confidence: 99%

The Protein Polymorphism of Haptoglobin in Korean Elite Athletes

Kang

et al. 2003

Med Princ Pract

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Objective: To investigate protein polymorphism of the haptoglobin (Hp) and the relationship between Hp phenotypes and anthropometric or biochemical parameters in elite Korean male athletes. Materials and Methods: Serum samples were collected from 120 Korean male elite athletes. The Hp phenotypes were determined by polyacrylamide gel electrophoresis, followed by peroxidase staining. Then anthropometric or biochemical measurements were made: body composition, blood pressures, ventilatory responses, cholesterol (total, LDL cholesterol and HDL cholesterol), triglyceride, apolipoprotein A1, lipoprotein (a), creatine phosphokinase and lactate dehydrogenase. Results: The gene frequencies of the Hp1-1, Hp2-1 and Hp2-2 phenotypes in Korean male athletes were 12, 37 and 51%, respectively; this polymorphism was significantly associated with the VO_2max index in the athletes. An excess of the Hp1 allele was also observed in marathon runners compared with the other sporting activities, although it did not have any statistical significance. Conclusion: Hp polymorphism exists in elite Korean male athletes and Hp phenotype may be a useful marker for endurance performance in these male athletes.

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Haptoglobin 2-2 phenotype is associated with decreased ferroxidase activity in smokers

Awadallah

2003

Clinica Chimica Acta

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Haptoglobin Polymorphism in Korean Patients with Cardiovascular Diseases

Cited by 5 publications

References 7 publications

Evaluation of haptoglobin phenotypes in acute myocardial infarction (AMI) and their association with some risk factors

Evaluation of haptoglobin phenotypes in acute myocardial infarction (AMI) and their association with some risk factors

The Protein Polymorphism of Haptoglobin in Korean Elite Athletes

Haptoglobin 2-2 phenotype is associated with decreased ferroxidase activity in smokers

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