Haptoglobin types and subtypes in Alzheimer's disease and senile dementia

Velde, Wybrand Op den; Stam, Frank

doi:10.1007/bf00280872

Cited by 8 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A key difference between the two alleles is that the protein product produced by the HP1 allele has a stronger antioxidant ability than that produced by the HP2 allele (Melamed-Frank et al, 2001). As early as 1973, it was reported that both HP 1-2 and HP 2-2 genotypes were significantly increased in patients with early-onset dementia (Op den Velde and Stam, 1973). Similar results were obtained in diabetic patients by many following studies in recent years, and HP 1-1 genotype was considered to be associated with poorer cognitive functioning due to greater susceptibility to cerebrovascular diseases, whereas the HP2 allele enhanced the gene expression of an angiogenic factor in endothelial progenitor cells and may improve blood perfusion and recovery after an ischemic injury (German et al, 2007;Ravona-Springer et al, 2013;Wang et al, 2015;Beeri et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Label-Free Liquid Chromatography–Mass Spectrometry Proteomic Analysis of Urinary Identification in Diabetic Vascular Dementia in a Han Chinese Population

Chen

Xiao

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

Objective: This study aimed to identify potential diagnostic biomarkers of diabetic vascular dementia (DVD) and unravel the underlying mechanisms using mass spectrometry (MS).Methods: Label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomic analysis was applied to urine samples from four groups, including 14 patients with vascular dementia (VD), 22 patients with type 2 diabetes mellitus (T2DM), 12 patients with DVD, and 21 normal controls (NCs). Searching the MS data by Proteome Discoverer software (ThermoFisher Scientific; Waltham, MA, USA), protein abundances were analyzed qualitatively and quantitatively and compared between these groups. Combining bioinformatics analysis using Gene Ontology (GO), pathway crosstalk analysis using Kyoto Encyclopedia of Genes and Genomes (KEGG), protein–protein interaction (PPI) network analysis using STRING, and literature searching, the differentially expressed proteins (DEPs) of DVD can be comprehensively judged and were further quantified by receiver operating characteristic (ROC) curve methods.Results: The proteomic findings showed quantitative changes in patients with DVD compared to patients with NC, T2DM, and VD groups; among 4,744 identified urine proteins, 1,222, 1,152, and 1,180 proteins displayed quantitative changes unique to DVD vs. NC, T2DM, and VD, respectively, including 481 overlapped common DEPs. Then, nine unique proteins [including HP, SERPIND, ATP5PB, VNN2, ALDH3A1, U2AF2, C6, A0A5C2GRG5 (no name), and A0A5C2FZ29 (no name)] and two composite markers (CM) (A0A5C2GRG5+U2AF2 and U2AF2+C6) were confirmed by a ROC curve method.Conclusion: This study provided an insight into the potential pathogenesis of DVD and elucidated a method for early detection.

show abstract

Section: Discussionmentioning

confidence: 99%

Label-Free Liquid Chromatography–Mass Spectrometry Proteomic Analysis of Urinary Identification in Diabetic Vascular Dementia in a Han Chinese Population

Chen

Xiao

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

Orotic Acid in Urine and Hyperammonemia

Bachmann

Colombo

1982

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Haptoglobintypen bei chronischen lebererkrankungen

Blenk

Junge

1978

Klin Wochenschr

View full text Add to dashboard Cite

The distribution of haptoglobin phenotypes (Hp) 1--1, 2--1 and 2--2 in 174 patients suffering from liver cirrhosis was determined and compared with a reference group consisting of 194 healthy subjects. The study revealed a high frequency of the Hp 1--1 phenotype (32%) in the patients as compared with the control group (14%). This difference is statistically highly significant (p less than 0.00025). It was calculated that in individuals of type Hp 1--1, the risk of liver cirrhosis is 4.3-fold higher than in persons with the phenotype Hp 2--2.

show abstract

Haptoglobin types and subtypes in Alzheimer's disease and senile dementia

Cited by 8 publications

References 12 publications

Label-Free Liquid Chromatography–Mass Spectrometry Proteomic Analysis of Urinary Identification in Diabetic Vascular Dementia in a Han Chinese Population

Label-Free Liquid Chromatography–Mass Spectrometry Proteomic Analysis of Urinary Identification in Diabetic Vascular Dementia in a Han Chinese Population

Orotic Acid in Urine and Hyperammonemia

Haptoglobintypen bei chronischen lebererkrankungen

Contact Info

Product

Resources

About