Haptoglobin

Giblett, Eloise R.

doi:10.1007/978-1-4684-2676-2_3

Cited by 24 publications

(16 citation statements)

References 59 publications

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“…Hp, which was identified in two different tissue specimens in the present study, is an acute-phase protein (a serum polypeptide synthesized by hepatocytes) (41). Nonetheless, the colorectal epithelium expression of Hp has also been previously reported (42,43).…”

Section: Discussionsupporting

confidence: 57%

Identification of proteins with the CDw75 epitope in human colorectal cancer

2017

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Abstract. The CDw75 epitope is an α(2,6) sialylated antigen overexpressed in colorectal cancer (CRC), where its expression correlates with the progression of the disease. The CDw75 epitope is located mainly in N-glycoproteins, whose identity remains unknown. The aim of the present study was to identify proteins with the CDw75 epitope as a strategy to deepen the understanding of molecular pathogenesis of CRC and to identify novel biomarkers for this disease. For this purpose, a two-dimensional electrophoresis approach was employed. Protein spots in the gels were matched to the corresponding CDw75 positive spots in the immunoblotted polyvinylidene difluoride membranes, and further identification of the protein species was performed by mass spectrometry. Additionally, one-dimensional western blotting experiments were performed to verify the expression of these candidate proteins in the colorectal tissue and their coincidence in molecular mass with the CDw75-positive bands. The findings of the present study indicate that haptoglobin and the keratins 8 (K8) and 18 (K18) are proteins with the CDw75 epitope in the colorectal tissue from CRC patients and also suggest novel functions and cellular locations for these proteins in the colorectal tissue and in relation to CRC.

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Section: Discussionsupporting

confidence: 57%

Identification of proteins with the CDw75 epitope in human colorectal cancer

2017

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“…This hypothesis is confirmed by the lower value of HP; that is considered to bind free haemoglobin (Hb) derived from inflammation processes in a stoichiometric ratio in vivo and in vitro. The resultant HP-Hb complex is rapidly removed from the circulation by the reticuloendothelial system [55]. Moreover, these animals showed the higher moving and foraging activities and the consequent higher ROS haematic concentration, but accompanied by an increased haematic AP value that permitted to animal to adapt to the higher oxidative metabolism [56].…”

Section: Discussionmentioning

confidence: 99%

Effect of Genotype and Husbandry System on Blood Parameters, Oxidative and Native Immune Status: Welfare and Implications on Performance of Organic Laying Hens

Mugnai¹

2011

TOVSJ

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Abstract:The aim of the present work was to compare the effect of organic production vs standard cage system on welfare and performance of a pure breed (Ancona) vs a commercial strain (Brown Hy-Line) of laying hens through a multifunctional approach (behaviour, tonic immobility, feathers score, antioxidant status of the body, blood parameters, innate immunity and mortality). The trial was carried out in farm of the Dpt. of Applied Biology (University of Perugia), where 17-weeks-old females of Ancona breed (n=200) and Brown Hy-Line (n=200) were divided in 2 homogenous groups of 100 birds each and assigned to cage or organic rearing systems.The genotype of the hens affected in a degree which depends on rearing system almost all the variables. The feeding and resting activities were higher in caged whereas moving activities were higher in organic hens and especially in Ancona birds. Social relationships showed genotype and rearing system effects being higher in Brown Hy-Line hens particularly when reared in cage. The TI duration was affected by genotype and rearing system being the immobility time longer in Brown Hy-Line. The plumage condition showed a great rearing system effect and genotype effects was observed only between organic groups where Ancona hens showed the better feathers condition. Regarding native immune status serum bactericidal activity showed the highest values in organic hens and mainly in Ancona ones. On the contrary, lysozyme showed greater value in caged hens. The haptoglobin value was lower in organic Ancona group, the same hens showed about 30% greater reactive oxygen substances, but accompanied by highest the antioxidant power. Organic rearing system, mainly in the Ancona hens, induced the highest red blood cells, haemoglobin and hematocrite values. Lymphocytes were higher in Organic birds thus reducing the H/L ratio in Organic hens. As expected, organic birds showed the worst feed efficiency and percentage of deposition, but the lowest mortality rate. In conclusion, on the basis of all these information together with the low mortality rate, Ancona hens showed the better welfare status, mainly when they were organically reared.

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“…The intravascular destruction of erythrocytes, which accounts for~10%-20% of the normal destruction of erythrocytes, releases free hemoglobin (Hb) into the general circulation. The primary function of Hp is to bind to this Hb, thereby preventing the renal excretion of iron and protecting blood vessels from the oxidative effects of this protein (Giblett, 1968). Even when the destruction is mainly extravascular, some erythrocytes still undergo lysis in the intravascular compartment, as shown by the reduced serum levels of Hp in sickle cell diseases and thalassemias (Hillman and Finch, 1992).…”

Section: Human Haptoglobinmentioning

confidence: 99%

Polymorphism of human haptoglobin and its clinical importance

2008

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Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders.

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Haptoglobin

Cited by 24 publications

References 59 publications

Identification of proteins with the CDw75 epitope in human colorectal cancer

Identification of proteins with the CDw75 epitope in human colorectal cancer

Effect of Genotype and Husbandry System on Blood Parameters, Oxidative and Native Immune Status: Welfare and Implications on Performance of Organic Laying Hens

Polymorphism of human haptoglobin and its clinical importance

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