Hard Metal Disease and Tool Room Grinding

Bech, A. O.

doi:10.1093/occmed/24.1.11

Cited by 24 publications

(13 citation statements)

References 4 publications

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“…Thus, in some patients the pathology may be more reminiscent of mixed dust pneumoconiosis. 19 Finally, one could argue that, in terms of management, it is more useful to label a disease according to its etiology than according to its pathology.…”

Section: Giant Cell Interstitial Pneumoniamentioning

confidence: 99%

Giant Cell Interstitial Pneumonia (Hard Metal Lung Disease, Cobalt Lung)

Nemery¹,

Verbeken²,

Demedts³

2001

Seminars in Respiratory and Critical Care Medicine

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Hard metal lung disease is a rare form of occupational lung disease that can occur in workers engaged in the manufacture, utilization, or maintenance of tools composed of hard metal [a material composed mainly of tungsten carbide (WC) and cobalt] or diamond-cobalt. Clinically, the condition resembles hypersensitivity pneumonitis, with subacute presentations and possible evolution to pulmonary fibrosis. However, this interstitial lung disease is uniquely characterized by the presence of bizarre ;;cannibalistic'' multinucleated giant cells in the alveoli and the bronchoalveolar lavage. A pathological diagnosis of giant cell interstitial pneumonitis (GIP) is, therefore, specific for hard metal lung disease, even though not all affected subjects exhibit this pathognomonic feature. Cobalt is the critical toxic component causing hard metal lung disease, hence also the term cobalt-lung. Hard metal lung disease is more likely to occur in poorly regulated workplaces, but its occurrence depends mainly on individual susceptibility, rather than on cumulative exposure, so that even young subjects may be affected.

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Section: Giant Cell Interstitial Pneumoniamentioning

confidence: 99%

Giant Cell Interstitial Pneumonia (Hard Metal Lung Disease, Cobalt Lung)

Nemery¹,

Verbeken²,

Demedts³

2001

Seminars in Respiratory and Critical Care Medicine

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“…The respiratory diseases pneumoconiosis and bronchial asthma are known to be caused by exposure to hard metal dust.1-3) Cobalt added to tungsten carbide (WC) powder in small amounts is considered to be the causative agent for these respiratory diseases [4][5][6] In 1966, the American Conference of Governmental Industrial Hygienists (ACGIH) proposed the threshold limit value of time-weighted average concentration (TLV-TWA) of cobalt exposure as 0.1 mg/m3. However, an experimental study7)…”

Section: Introductionmentioning

confidence: 99%

Analysis of dusts and evaluation of dust exposure in a hard metal factory.

et al. 1987

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“…This may be accompanied by cor pulmonale (heart enlargement and failure due to the lung disease), leading ultimately to cardiorespiratory collapse and death.a The reported latency period from exposure to disease varies from a few years to 20 years. Several investigators have suggested evidence of bronchitis among hard metal workers.11-24 Asthma has been reported (11,12,25,26) as early as within one month after initial exposure. 25 The development of asthma seems to be a true sensitization to cobalt.…”

Section: Cobalt and Tqngst!n Carbidementioning

confidence: 99%

Health hazard evaluation report: HETA-85-295-1907, General Electric Carboloy Systems, Detroit, Michigan.

1988

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Hard Metal Disease and Tool Room Grinding

Cited by 24 publications

References 4 publications

Giant Cell Interstitial Pneumonia (Hard Metal Lung Disease, Cobalt Lung)

Giant Cell Interstitial Pneumonia (Hard Metal Lung Disease, Cobalt Lung)

Analysis of dusts and evaluation of dust exposure in a hard metal factory.

Health hazard evaluation report: HETA-85-295-1907, General Electric Carboloy Systems, Detroit, Michigan.

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