Hard tissue engineering applications

Farid, Saad B. H.

doi:10.1016/b978-0-08-102233-7.00005-7

Cited by 8 publications

(11 citation statements)

References 135 publications

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“…The use of scaffold is an essential factor for hard tissue regeneration by providing desired surface and space for cells to attach, proliferate, migrate, and differentiate to organize a normal bone tissue (Gómez-Lizárraga et al, 2017;Ishack et al, 2017;Kumar et al, 2017b;Farid, 2019). For hard tissue reconstruction, biodegradability, biocompatibility, osteoconductivity, desired pore-interconnected microstructure, and suitable mechanical performance are critical characteristics of tissue-engineered scaffolding system (Zhang et al, 2019).…”

Section: Hard Tissue Regenerationmentioning

confidence: 99%

“…The controlled dissolution of bioceramic implants upon contact with biological solutions provides the in vivo threedimensional (3D) micro-/nanoenvironment with desired ions that improve the growth of native tissue. Therefore, the selection of material type and design for hard tissue regeneration is a great challenge to achieve native 3D micro-/nanoenvironment (Farid, 2019).…”

Section: Hard Tissue Regenerationmentioning

confidence: 99%

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Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

et al. 2019

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Hydroxyapatite (HAp) has been considered for decades an ideal biomaterial for bone repair due to its compositional and crystallographic similarity to bioapatites in hard tissues. However, fabrication of porous HAp acting as a template (scaffold) for supporting bone regeneration and growth has been a challenge to biomaterials scientists. The introduction of additive manufacturing technologies, which provide the advantages of a relatively fast, precise, controllable, and potentially scalable fabrication process, has opened new horizons in the field of bioceramic scaffolds. This review focuses on three-dimensional-printed HAp scaffolds and related composite systems, where the calcium phosphate phase is combined with other ceramics or polymers improving the mechanical properties and/or imparting special extra-functionalities. The main applications of three-dimensional-printed HAp scaffolds in bone tissue engineering are presented and discussed; furthermore, this review also emphasizes the most recent achievements toward the development and testing of multifunctional HAp-based systems combining multiple properties for advanced therapy (e.g., bone regeneration, antibacterial effect, angiogenesis, and cancer treatment).

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Section: Hard Tissue Regenerationmentioning

confidence: 99%

Section: Hard Tissue Regenerationmentioning

confidence: 99%

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

et al. 2019

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“…In conjunction with direct observation of the microstructure, density measurements provided reliable information for the densification of the sintered materials. In the present study, the outstanding precision of this method 16 allowed to determine small density differences, such the density of tetragonal and cubic zirconia (which is 6.10 and 6.06 g/cm 3 , respectively) 15,17 . Moreover, these measurements were able to determine possible “overfiring” effects (i.e., abnormal grain growth or formation of hollow holes in the bulk of the sintered material), caused after sintering of zirconia at high temperatures (>1600°C) 18 .…”

Section: Introductionmentioning

confidence: 70%

Microstructural features, physicο‐mechanical properties, and wear behavior of dental translucent polychromic multilayer zirconia of hybrid composition prepared by milling technology

Dimitriadis

Constantinou

Moschovas

et al. 2023

J Esthet Restor Dent

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ObjectiveThe present study determined the mechanical properties and the wear behavior, as results of the micro(nano)structure, of the enamel, transition, and dentine layers, which comprise the polychromic multilayer zirconia materials of hybrid composition fabricated by milling technology.Materials and MethodsPrismatic blocks were fabricated from two commercial pre‐sintered dental polychromic multilayer zirconia materials of hybrid composition, IPS e.max ZirCAD Prime (medium and high translucency, from the dentine to the incisal layer) and 3D Pro ML (translucency gradient, from the dentine to the incisal layer) by milling technique, and then, cut into 3 distinct parts to separate the enamel, transition, and dentine layers. The samples were sintered, thermally treated (similarly to the glazing procedure), and polished for characterization. Their microstructure, mechanical properties (determined by nanoindentation and microhardness), and wear behavior (evaluated by scratch test), were examined.ResultsThe produced materials had a homogeneous and dense nanostructure, where the grain size decreased from the enamel to dentine layer. The mechanical properties also decreased from the enamel to dentine layer. However, the three layers manifested similar dynamic friction coefficient.ConclusionThe differences in the above properties in the three layers negligibly influenced the wear behavior of the entire multilayer zirconia material.Clinical SignificanceThe properties of dental restorations produced from polychromic multilayer zirconia of hybrid composition by milling technology (i.e., strong, non‐fragile, and esthetic materials), anticipate good performance in oral cavity.

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“…These ceramics are commonly integrated with bone tissues via chemical reactions which leads to the formation of hydroxycarbonate apatite without any inflammation. The bond (formed between the bone tissues and bioactive ceramics) is stronger than the bone itself [144]. Common examples of these ceramics are bioglass and calcium phosphates [145], [146].…”

Section: Bioceramicsmentioning

confidence: 99%

“…for bone replacement applications [146]. HA(Ca 10 (PO 4 ) 6 (OH) 2 ) is a bioactive ceramic with structure and chemistry in close resemblance with bone minerals and finds applications in scaffolds [144]. These ceramics are designed to undergo gradual degradation in a predetermined time frame.…”

Section: Bioceramicsmentioning

confidence: 99%