Abstract:Next‐generation sequencing techniques have dramatically increased the amount of genomic data being sequenced, which calls for the acceleration of the alignment algorithms. This article proposes an FPGA‐based accelerated implementation of the seed extension kernel of the Burrows–Wheeler alignment genomic mapping algorithm. The well‐known Smith–Waterman algorithm is used during the seed extension to find the optimum alignment between the sequences. The state‐of‐the‐art architectures in the literature use one‐dim… Show more
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