Abstract-Multichannel neural recording is one of the most important topics in the field of biomedical engineering. This is because there is a need to considerably reduce large amounts of data without degrading the data quality for easy transfer through wireless transmission. Video compression technology is of considerable importance in the field of signal processing. There are many similarities between multichannel neural signals and video signals. In this study, we propose a signal compression method that employs motion vectors (MVs) to reduce the redundancy between successive video frames and between successive channels. The method shows a signal-to-noise (error) ratio (SNR) of 25 db and data are compressed to 5% of their original size.