Harmaline ingestion effect on development, metabolites and midgut of the red flour beetle, Tribolium castaneum

Rharrabe, Kacem; Jbilou, Rachid; Bouayad, Noureddin; Ajaha, Ayoub; Aarab, Ahmed

doi:10.1016/j.aspen.2019.10.013

Cited by 5 publications

(3 citation statements)

References 45 publications

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“…One explanation can be the usage of FA for the synthesis of cuticle components or pheromones, which is in accord with studies indicating that alkaloids from Cynanchum komarovii increase the relative content of lipids in the cuticle in S. litura larvae [50]. However, the total lipid content in T. castaneum treated with harmaline decreased [51], while another alkaloid, nicotine, did not affect lipid stores in honeybee pupae [52]. In summary, GAs change the lipid profile in beetle tissues and affect the activity of enzymes crucial for lipid metabolism.…”

Section: Discussionsupporting

confidence: 79%

Solanaceae Glycoalkaloids Disturb Lipid Metabolism in the Tenebrio molitor Beetle

Winkiel,

Chowański,

Gołębiowski

et al. 2023

Metabolites

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Glycoalkaloids (GAs) are produced naturally by plants and affect insect survivability and fertility. These compounds can be considered potential bioinsecticides; however, the mechanisms and effects of their action remain undiscovered. As lipids are essential molecules for the proper functioning of an insect organism, this research aimed to determine the effects of GAs on the lipid metabolism of the Tenebrio molitor beetle. Solanine, chaconine, tomatine, and tomato leaf extract were applied to larvae by injection at two concentrations, 10−8 and 10−5 M. Then, the tissue was isolated after 2 and 24 h to determine the levels of free fatty acids, sterols and esters using the GC–MS technique. Moreover, the triacylglyceride level and the activity of the key β-oxidation enzyme, 3-hydroxyacyl-CoA dehydrogenase (HADH), were measured. The results indicate that GAs affect the content and composition of lipid compounds in the beetles’ haemolymph and fat body. The effects depend on the GA concentrations, incubation time, and kind of tissue. Moreover, the tested compounds decrease HADH activity, especially in the fat body, which may affect energy production. To our knowledge, this is the first study concerning lipid metabolism in T. molitor after GA application. Our results provide some insights into that topic.

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Section: Discussionsupporting

confidence: 79%

Solanaceae Glycoalkaloids Disturb Lipid Metabolism in the Tenebrio molitor Beetle

Winkiel,

Chowański,

Gołębiowski

et al. 2023

Metabolites

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“…It is well known that alkaloids also can exert a feeding deterrent action against numerous insects, such as Choristoneura fumiferana [ 71 ] and Spodoptera littoralis [ 72 ]. Other alkaloids such as harmaline and hermidine again affect the growth and development of insects, including Tribolium castaneum , but their modes of action are not fully understood [ 73 ]. Ryanodine, an alkaloid compound from the plant species Ryania speciosa , exerts a strong insecticidal activity, acting at the sarcoplasmic reticulum, with ryanodine receptors influencing the secretion of Ca 2+ [ 74 ].…”

Section: Botanical Insecticidesmentioning

confidence: 99%

Status and Prospects of Botanical Biopesticides in Europe and Mediterranean Countries

Acheuk

Basiouni

Shehata³

et al. 2022

Biomolecules

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Concerning human and environmental health, safe alternatives to synthetic pesticides are urgently needed. Many of the currently used synthetic pesticides are not authorized for application in organic agriculture. In addition, the developed resistances of various pests against classical pesticides necessitate the urgent demand for efficient and safe products with novel modes of action. Botanical pesticides are assumed to be effective against various crop pests, and they are easily biodegradable and available in high quantities and at a reasonable cost. Many of them may act by diverse yet unexplored mechanisms of action. It is therefore surprising that only few plant species have been developed for commercial usage as biopesticides. This article reviews the status of botanical pesticides, especially in Europe and Mediterranean countries, deepening their active principles and mechanisms of action. Moreover, some constraints and challenges in the development of novel biopesticides are highlighted.

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“…Ginsenosides caused the activity of glutathione S-tranterase, acetylcholine esterase and carboxyl esterase to decrease, but the activity of mixed-function oxidase to increase (Yang et al, 2018). The addition of leaf extracts containing alkaloids can be beneficial as a feeding inhibitor against Tribolium castaneum larvae because it decreases the activity of the α-amylase enzyme (Rharrabe et al, 2020). In addition, several active compounds in plant extracts together produce a stronger more pungent aroma for insects that can affect the performance of the taste buds and affect eating activity, causing reduced consumption (Widiyaningrum et al, 2020).…”

Section: Feeding Activity Bioassaymentioning

confidence: 99%

Active compounds and biological activities of geranium aralia (Polyscias guilfoylei (W. Bull) L.H. Bailey) leaf extract against larval stage of melon fly (Zeugodacus cucurbitae Coquillett)

2022

ANRES

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Importance of the work:Polyscias guilfoylei is a shrub that is known as a medicinal plant whose leaf extracts contain active compounds, such as saponins. Objectives: To determine the active compounds and biological activities of P. guilfoylei leaf extracts against Zeugodacus cucurbitae. Materials & Methods: The research was conducted in the Plant Pest Laboratory using a randomized block design arranged in a factorial manner. The solvents used were ethanol and n-hexane at concentrations of 0%, 1.25%, 2.50% and 5.00%. All treatments were replicated four times. The parameters observed were: active compound content, larval feeding and growth activities. Results: Ultraviolet-visible spectrophotometry and thin layer chromatography indicated that the ethanol P. guilfoylei leaf extracts contained phenols, tannins, alkaloids, flavonoids and saponins, while the n-hexane P. guilfoylei leaf extracts contained terpenoids, steroids, phenols, tannins, alkaloids, flavonoids and saponins. Application of 5.00% ethanol or n-hexane P. guilfoylei leaf extracts caused lower values for feeding activity and the feeding deterrent index. In addition, the extracts affected larval and pupal periods, the number of larvae reaching pupation and the pupal weight of Z. cucurbitae. Application of higher concentrations of extracts resulted in longer larval and pupal periods, a reduced pupal weight and fewer larvae reaching the pupal stage. Main finding: The active compounds in P. guilfoylei leaf extracts were phenols, tannins, alkaloids, flavonoids and saponins. Application of leaf extract at up to 5.00% could deter larval feeding and the growth activities of Z. cucurbitae.

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Harmaline ingestion effect on development, metabolites and midgut of the red flour beetle, Tribolium castaneum

Cited by 5 publications

References 45 publications

Solanaceae Glycoalkaloids Disturb Lipid Metabolism in the Tenebrio molitor Beetle

Solanaceae Glycoalkaloids Disturb Lipid Metabolism in the Tenebrio molitor Beetle

Status and Prospects of Botanical Biopesticides in Europe and Mediterranean Countries

Active compounds and biological activities of geranium aralia (Polyscias guilfoylei (W. Bull) L.H. Bailey) leaf extract against larval stage of melon fly (Zeugodacus cucurbitae Coquillett)

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