Harmful Effect of Preformed Anti-MICA Antibodies on Renal Allograft Evolution in Early Posttransplantation Period

Sánchez-Zapardiel, Elena; Castro-Panete, María José; Castillo-Rama, Marcela; Morales, Pablo; Lora-Pablos, David; Valero-Hervás, D.M.; Ruiz‐García, Raquel; Apaza, Jacqueline; Talayero, Paloma; Andrés, Amado; Morales, José; Paz-Artal, Estela

doi:10.1097/tp.0b013e3182943506

Cited by 29 publications

(28 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a more recent and large cohort study, Sánchez‐Zapardiel et al. also showed that in patients without anti‐HLA antibodies, pre‐transplantation anti‐MICA antibodies significantly increased the rejection rate at 3 and 6 months (p = 0.032, 0.046). To summarize, it is not clear whether MICA antibodies are associated with allograft survival, and more studies are required (Table ).…”

Section: Mica In Renal Transplantationmentioning

confidence: 94%

Role of MICA antibodies in solid organ transplantation

Luo

et al. 2013

Clinical Transplantation

View full text Add to dashboard Cite

As a potential transplant antigen, major histocompatibility complex class I chain-related gene A (MICA) antigen, has attracted increased attention because of its possible role in solid organ transplantation. There are two MICA forms, and MICA antibodies and soluble MICA (sMICA) have been found in the serum of transplant recipients. We searched MEDLINE, EMBASE, and the Cochrane Library for original reports of clinical studies involving the effect of MICA on outcomes of renal, heart, lung, and liver transplantation. In addition to the human leukocyte antigen antigens, which elicit a strong immune response, the polymorphic MICA antigens induce production of MICA antibodies and sMICA. A number of clinical studies have shown that MICA antibodies correlate with an increased incidence of rejection and a decreased allograft survival rate following renal or heart transplantation. Although it is clearly associated with chronic rejection of lung allografts, no such correlation was found for liver transplantation. Moreover, sMICA showed a negative association with acute rejection (AR) and may be a good predictor of heart transplant outcomes. These data suggest MICA expression patterns and regulatory function may be tissue specific and that different transplants have different organ-specific outcomes.

show abstract

Section: Mica In Renal Transplantationmentioning

confidence: 94%

Role of MICA antibodies in solid organ transplantation

Luo

et al. 2013

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

“…We retrospectively analysed 727 consecutive kidney allograft recipients transplanted between 2005 and 2011 in our hospital (cohort previously described [10]). The study was performed under informed consent and approved by the institutional review board (reference 10/014).…”

Section: Patients and Samplesmentioning

confidence: 99%

“…Anti-MICA-specific antibody and C1q binding assays Anti-MICA-positive samples in the screening test [10] were tested by Luminex ® for individual anti-MICA specificities [Luminex single-antigen (LSA) assay, LABScreen MICA Single Antigen kit, One Lambda, Canoga Park, CA, USA]: 001, 002, 004, 007, 009, 012, 015, 017, 018, 019 or 027. C1q binding was tested in LSA-positive samples with the C1qScreen™ kit.…”

Section: Patients and Samplesmentioning

confidence: 99%

“…C y t o t o x i c a n t i -M I C A a n t i b o d i e s i n t r a n s p l a n t regarding sex and age of donor and recipient, donor type, immunosuppressive treatments and original disease [10].…”

Section: O R I G I N a L A R T I C L Ementioning

confidence: 99%

“…In an analysis of 727 kidney recipients, we obtained similar results. By categorizing transplanted patients either according to pre-transplant panel reactivity antibody (PRA) and anti-MICA sensitization status or to anti-HLA and anti-MICA sensitization status, we reported decreased graft survival in PRA + MICA + patients and the highest risk for rejection at Month 3 in HLA − MICA + patients [10].…”

mentioning

confidence: 99%

See 2 more Smart Citations