Harmonic Imaging of Stem Cells in Whole Blood at GHz Pixel Rate
Sebastian Karpf,
Nina Glöckner Burmeister,
Laurence Dubreil
et al.
Abstract:The pre‐clinical validation of cell therapies requires monitoring the biodistribution of transplanted cells in tissues of host organisms. Real‐time detection of these cells in the circulatory system and identification of their aggregation state is a crucial piece of information, but necessitates deep penetration and fast imaging with high selectivity, subcellular resolution, and high throughput. In this study, multiphoton‐based in‐flow detection of human stem cells in whole, unfiltered blood is demonstrated in… Show more
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