In this paper, some classes much more general than the one in [N.M. Chuong, Yu.V. Egorov, A. Khrennikov, Y. Meyer, D. Mumford (Eds.), Harmonic, Wavelet and p-Adic Analysis, World Scientific, Singapore, 2007] of Cauchy problems for an interesting class of pseudodifferential equations over p-adic fields are studied. The used functions belong to mixed classes of real and p-adic functions. Even for p-adic partial differential equations such problems in such function spaces have not been discussed yet. The established mathematical foundation requires very complicated and very difficult proofs. Days after days, these equations occur increasingly in mathematical physics, quantum mechanics. Explicit solutions of such problems are very needed for specialists on applied mathematics, physics, and engineering.