Harmonising Individual Patient Level Cardiac Registry Data Across the Asia Pacific Region—A Feasibility Study of In-Hospital Outcomes of STEMI Patients From the Asia Pacific Evaluation of Cardiovascular Therapies (ASPECT) Network

Reid, C.; Chih, HuiJun; Duffy, Stephen J.; Brennan, A.; Ajani, A.; Beltrame, John F.; Tavella, Rosanna; Yan, Bryan P.; Dinh, D.; Chin, Chee Tang; Loi, Doan Huy; Nguyen, Quang Ngoc; Hoai, Nguyen Thi Thu; Wijaya, Ika Prasetya; Yamin, Muhammad; Rusdi, Lusiani; Alwi, Idrus; Sim, Kui Hian; Fong, Alan Yean Yip; Ahmad, Wan Azman Wan; Yeo, Khung Keong

doi:10.1016/j.hlc.2022.08.012

Heart, Lung and Circulation

2023

DOI: 10.1016/j.hlc.2022.08.012

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Harmonising Individual Patient Level Cardiac Registry Data Across the Asia Pacific Region—A Feasibility Study of In-Hospital Outcomes of STEMI Patients From the Asia Pacific Evaluation of Cardiovascular Therapies (ASPECT) Network

C. Reid¹,

HuiJun Chih²,

Stephen J. Duffy³

et al.

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2024

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Clinical outcomes and coronary artery lesion characteristics of young patients with ST elevation myocardial infarction and no standard modifiable risk factors

Lan,

Chih,

Brennan

et al. 2024

Cathet Cardio Intervent

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BackgroundAmong ST‐elevation myocardial infarction (STEMI) patients, those with no standard modifiable risk factors (SMuRFs: hypertension, diabetes mellitus, hypercholesterolemia, and smoking) have higher 30‐day mortality than those with SMuRFs. Differences in coronary lesion characteristics remain unclear.MethodsData from STEMI patients aged ≤60 years from the Asia Pacific Evaluation of Cardiovascular Therapies Network (Australia, Hong Kong, Malaysia, Singapore, and Vietnam) was retrospectively analysed. Exclusion criteria included incomplete SMuRF data, prior myocardial infarction, or prior coronary revascularisation. Lesion type was defined using the American College of Cardiology criteria. Major adverse cardiovascular events (MACE) were defined as peri‐procedural myocardial infarction, emergency coronary artery bypass surgery, cerebrovascular event, or mortality. Multiple logistic regressions were used.ResultsOf 4404 patients, 767 (17.4%) were SMuRFless. SMuRFless patients were more frequently younger (median age 51 vs. 53 years; p < 0.001), female (22.6% vs. 15.5%; p < 0.001), thrombolysed (20.1% vs. 12.5%; p < 0.001), and in cardiogenic shock (11.2% vs. 8.6%; p = 0.020). SMuRFless patients had significantly higher in‐hospital MACE (7.2% vs. 4.3%; adjusted odds ratio [aOR] 2.25; 95% confidence interval [CI] 1.24–4.08; p = 0.008) but 1‐year mortality was not significantly different (3.6% vs. 5.7%, aOR 0.58; 95% CI 0.06–6.12; p = 0.549). Compared with patients with SMuRFs (4918 lesions), the SMuRFless (940 lesions) had fewer type B2/C lesions (60.8% vs. 65.6%; p = 0.020) and fewer lesions ≥20 mm (51.1% vs. 57.1%; p = 0.002) but more procedural complications (5.1% vs. 2.7%; p < 0.001).ConclusionsAmong young STEMI patients, the SMuRFless have shorter and less complex lesions, but worse procedural and short‐term MACE outcomes.

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Clinical outcomes and coronary artery lesion characteristics of young patients with ST elevation myocardial infarction and no standard modifiable risk factors

Lan,

Chih,

Brennan

et al. 2024

Cathet Cardio Intervent

View full text Add to dashboard Cite

show abstract

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Harmonising Individual Patient Level Cardiac Registry Data Across the Asia Pacific Region—A Feasibility Study of In-Hospital Outcomes of STEMI Patients From the Asia Pacific Evaluation of Cardiovascular Therapies (ASPECT) Network

Cited by 1 publication

References 26 publications

Clinical outcomes and coronary artery lesion characteristics of young patients with ST elevation myocardial infarction and no standard modifiable risk factors

Clinical outcomes and coronary artery lesion characteristics of young patients with ST elevation myocardial infarction and no standard modifiable risk factors

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