Objectives: Racial discrimination experiences contribute to health disparities and can influence individuals’ health. Yet, pathways by which discrimination-related experiences affect alcohol craving remain understudied using experimental designs. Additionally, limited research has examined possible differential effects of “major” discrimination and microaggression experiences in everyday life on alcohol craving. This between-groups experiment examined causal effects of everyday racial discrimination on stress, negative emotions, and alcohol craving. We also tested indirect pathways by which discrimination-related experiences were linked to alcohol craving via stress and negative emotions. Method: People of color and Indigenous peoples participated in the study (N=184; Mage=23.90; 47.8% women; 48.9% community adults). Participants were randomized to one of four experimental conditions, in which they experienced in virtual environments either “major” discrimination, microinsult, microinvalidation, or daily hassles unrelated to race/racism. Participants’ levels of stress, negative emotions, and alcohol craving were assessed immediately before and after experimental simulations. Results: Compared to daily hassles unrelated to race/racism, simulated racial discrimination elicited greater stress and negative emotions. Daily hassles caused greater alcohol craving among those who endorsed higher levels of coping motives for drinking. We observed minimal differences in stress and negative emotions across the three racial discrimination conditions, and found no evidence supporting indirect links between racial discrimination and alcohol craving via stress and negative emotions. Conclusion: Everyday racial discrimination—regardless of intensity level—is more stressful than daily hassles unrelated to race/racism. Future research should examine cumulative effects of racial discrimination, and understanding individual difference factors that moderate its immediate and delayed effects.