Harnessing Addiction Neuroscience to Treat Obesity

Sketriené, Diana; Ch’ng, Sarah S.; Brown, Robyn M.

doi:10.2174/9789811423178121050005

Cited by 2 publications

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“…In susceptible individuals, this can lead to compulsivelike overeating, characterized by the difficulty to inhibit behaviour despite known negative consequences, eating past satiety, and overall loss of control over high-fat high-sugar (HFHS) food intake (Davis, 2013). In this respect, compulsive overeating of HFHS food is strikingly similar to behavioural and substance addictions (Volkow & Wise, 2005;Gearhardt et al, 2009;Smith & Robbins, 2013;Moore et al, 2017;Sketriene et al, 2020). Preclinical studies indicate that diet-induced obese rats have alterations in their brains akin to those observed in animal models of substance abuse (Brown et al, 2017;Derman & Ferrario, 2018;Oginsky & Ferrario, 2019;Lau et al, 2020).…”

Section: Author Manuscriptmentioning

confidence: 94%

N-acetylcysteine reduces ‘addiction-like’ behaviour towards high-fat high-sugar food in diet-induced obese rats

Sketriené

Battista

Brown

et al. 2019

Obesity Research & Clinical Practice

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Section: Author Manuscriptmentioning

confidence: 94%

N-acetylcysteine reduces ‘addiction-like’ behaviour towards high-fat high-sugar food in diet-induced obese rats

Sketriené

Battista

Brown

et al. 2019

Obesity Research & Clinical Practice

Self Cite

View full text Add to dashboard Cite

“…In susceptible individuals, this can lead to compulsive-like overeating, characterized by the difficulty to inhibit behaviour despite known negative consequences, eating past satiety and overall loss of control over high-fat high-sugar (HFHS) food intake (Davis, 2013). In this respect, compulsive overeating of HFHS food is strikingly similar to behavioural and substance addictions (Gearhardt et al, 2009;Moore et al, 2017;Sketriene et al, 2020;Smith & Robbins, 2013;Volkow & Wise, 2005). Preclinical studies indicate that dietinduced obese rats have alterations in their brains akin to those observed in animal models of substance abuse (Brown et al, 2017;Derman & Ferrario, 2018;Lau et al, 2020;Oginsky & Ferrario, 2019).…”

Section: Introductionmentioning

confidence: 99%

N‐acetylcysteine reduces addiction‐like behaviour towards high‐fat high‐sugar food in diet‐induced obese rats

Sketriené

Battista

Perry

et al. 2021

Eur J of Neuroscience

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Compulsive forms of eating displayed by some obese individuals share similarities with compulsive drug‐taking behaviour, a hallmark feature of substance use disorder. This raises the possibility that drug addiction treatments may show utility in the treatment of compulsive overeating. N‐Acetylcysteine (NAC) is a cysteine pro‐drug which has experienced some success in clinical trials, reducing cocaine, marijuana and cigarette use, as well as compulsive behaviours such as gambling and trichotillomania. We assessed the impact of NAC on addiction‐like behaviour towards highly palatable food in a rat model of diet‐induced obesity. Adult male Sprague–Dawley rats were placed on a high‐fat high‐sugar diet for 8 weeks and then assigned to diet‐induced obesity‐prone (DIO) or diet‐induced obesity‐resistant (DR) groups based on weight gain. DIO and DR rats were subjected to an operant conditioning paradigm whereby rats could lever press for high‐fat high‐sugar food pellets. This alternated with periods of signalled reward unavailability. Before treatment DIO rats ate more in their home cage, earned more food pellets in operant sessions, and responded more during periods that signalled reward unavailability (suggestive of compulsive‐like food seeking) compared with DR rats. This persistent responding in the absence of reward displayed by DIO rats was ameliorated by daily injections of NAC (100 mg/kg, i.p.) for 14 days. By the end of the treatment period, lever‐pressing by NAC‐treated DIO rats resembled that of DR rats. These findings suggest that NAC reduces addiction‐like behaviour towards food in rats and supports the potential use of this compound in compulsive overeating.

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Harnessing Addiction Neuroscience to Treat Obesity

Cited by 2 publications

References 0 publications

N-acetylcysteine reduces ‘addiction-like’ behaviour towards high-fat high-sugar food in diet-induced obese rats

N-acetylcysteine reduces ‘addiction-like’ behaviour towards high-fat high-sugar food in diet-induced obese rats

N‐acetylcysteine reduces addiction‐like behaviour towards high‐fat high‐sugar food in diet‐induced obese rats

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