Harnessing alginate-based nanocomposites as nucleic acid/gene delivery platforms to address diverse biomedical issues: A progressive review

Konwarh, Rocktotpal; Singh, Anand Pratap; Varadarajan, Vijayakumar; Cho, William C.

doi:10.1016/j.carpta.2023.100404

Carbohydrate Polymer Technologies and Applications

2024

DOI: 10.1016/j.carpta.2023.100404

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Harnessing alginate-based nanocomposites as nucleic acid/gene delivery platforms to address diverse biomedical issues: A progressive review

Rocktotpal Konwarh,

Anand Pratap Singh,

Vijayakumar Varadarajan

et al.

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2024

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Cited by 4 publications

References 150 publications

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Novel Carbohydrate Polymer‐Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials

Udaipuria,

Bhattacharya

2024

Biopolymers

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Due to their biocompatibility, biodegradability, and controlled release, carbohydrates polymers are crucial to targeted drug delivery systems, notably for colon cancer treatment. This article examines how carbohydrate polymers like chitosan, pectin, guar gum, alginate, hyaluronic acid, dextran, and chondroitin sulfate are used in improved drug delivery. Modifying these polymers improves drug loading, stability, and release patterns, enhancing chemotherapeutic drugs' therapeutic index. Chitosan nanoparticles are pH‐responsive, making them perfect for cancer treatment. Pectin's resistance to gastric enzymes and colonic bacteria makes it a promising colon‐specific medication delivery agent. The combination of these polymers with nanotechnology, 3D printing, and AI allows the creation of stimuli‐responsive systems that release drugs precisely in response to environmental signals like pH, redox potential, or colon enzymatic activity. The review highlights intelligent delivery system design advances that reduce systemic toxicity, improve treatment efficacy, and improve patient adherence. Carbohydrate polymers will revolutionize colon cancer treatment with personalized and accurate alternatives.

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Novel Carbohydrate Polymer‐Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials

Udaipuria,

Bhattacharya

2024

Biopolymers

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Enhancing biomedical imaging: the role of nanoparticle-based contrast agents

Habeeb,

Vengateswaran,

Tripathi

et al. 2024

Biomed Microdevices

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Modulating alginate-polyurethane elastomer properties: Influence of NCO/OH ratio with aliphatic diisocyanate

Usman,

Hussain,

Akram

et al. 2024

International Journal of Biological Macromolecules

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Harnessing alginate-based nanocomposites as nucleic acid/gene delivery platforms to address diverse biomedical issues: A progressive review

Cited by 4 publications

References 150 publications

Novel Carbohydrate Polymer‐Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials

Novel Carbohydrate Polymer‐Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials

Enhancing biomedical imaging: the role of nanoparticle-based contrast agents

Modulating alginate-polyurethane elastomer properties: Influence of NCO/OH ratio with aliphatic diisocyanate

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