Harnessing antimicrobial peptide-coupled photosensitizer to combat drug-resistant biofilm infections through enhanced photodynamic therapy

Fan, Duoyang; Liu, Xiaohui; Ren, Yueming; Luo, Ziheng; Li, Yanbing; Dong, Jie; Wegner, Seraphine V.; Chen, Fei; Zeng, Wenbin

doi:10.1016/j.apsb.2023.12.016

Cited by 12 publications

(3 citation statements)

References 47 publications

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“…TPI-PN was synthesized according to the literature procedure. 36 All other chemicals were purchased and purified using standard procedures.…”

Section: Methodsmentioning

confidence: 99%

“…The photosensitizer TPI-PN has good photodynamic activity, and the antimicrobial peptide HHC10 has been proved to have strong broad-spectrum antimicrobial activity in previous studies. 33–36 The hydrogel was formed by the Schiff base between the aldehyde group (−CHO) of OD and the amino group (−NH 2 ) of QCS. HHC10 and TPI-PN can also be combined into the hydrogel through the formation of imine bonds between structural amino groups and OD.…”

Section: Introductionmentioning

confidence: 99%

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A peptide-based pH-sensitive antibacterial hydrogel for healing drug-resistant biofilm-infected diabetic wounds

Fan,

Xie,

Liu

et al. 2024

J. Mater. Chem. B

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“…TPI-PN was synthesized according to the literature procedure. 36 All other chemicals were purchased and purified using standard procedures.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A peptide-based pH-sensitive antibacterial hydrogel for healing drug-resistant biofilm-infected diabetic wounds

Fan,

Xie,

Liu

et al. 2024

J. Mater. Chem. B

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“…Sun et al opted to coat Ce6 on cerium oxide nanoparticles to ensure aPDT performance while mitigating the side effect of localized ROS excess . While the combination of photosensitizers with antioxidants effectively overcomes the limitations of aPDT and achieves effective synergistic antibacterial and anti-inflammatory efficacy, most existing nanomaterials employing this bifunctionality face challenges, including complex synthesis processes, limitations in biocompatibility, poor water solubility, susceptibility to aggregation quenching, and high cost. − These obstacles hinder their broad application in wound therapy. Hence, the development of uncomplicated and efficient bifunctional nanomaterials, possessing photosensitizing properties and antioxidant functions for applications in wound healing, continues to be of significant importance.…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporally Controllable Bifunctional Micellar-Carbon Dot Supernanoparticles for Wounds Healing

Chen,

Hao,

Liu

et al. 2024

ACS Appl. Nano Mater.

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Antimicrobial photodynamic therapy (aPDT) serves as a robust alternative to antibiotics, effectively facilitating the healing of infected wounds and circumventing the risk of resistance. However, the clinical application of aPDT is constrained by the local overproduction of reactive oxygen species (ROS) post-treatment and the deficiencies associated with traditional photosensitizers. Utilizing the self-assembly property of Pluronic F-127 (F127), we successfully achieved the efficient coassembly of cerium-doped carbon dots (Ce-CDs), significantly enhancing the photodynamic antimicrobial efficiency of carbon dots through a straightforward and effective method. Simultaneously, the introduction of cerium imparts outstanding antioxidant efficiency to F127-Ce-CDs (F-Ce-CDs), efficiently clearing overexpressed ROS at the site of infected wounds and protecting cells against oxidative stress. Moreover, F-Ce-CDs exhibit favorable biocompatibility and can significantly accelerate the migration of epithelial cells. In a murine model of infected wounds, F-Ce-CDs effectively inhibit bacterial activity and reduce inflammation, promoting collagen deposition and epithelial tissue regeneration, thereby accelerating the wound-healing process. With effective antimicrobial, anti-inflammatory, and antioxidant properties, coupled with excellent biocompatibility, F-Ce-CDs demonstrate substantial promise as a remarkably efficient application for safe and effective dressings in the healing of infected wounds.

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Stem Cell‐Derived Nanovesicles Embedded in Dual‐Layered Hydrogel for Programmed ROS Regulation and Comprehensive Tissue Regeneration in Burn Wound Healing

Zhao,

Kang,

Wang

et al. 2024

Advanced Materials

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Burn wounds often bring high risks of delayed healing process and even death. Reactive oxygen species (ROS) play a crucial role in burn wound repair. However, the dynamic process in wound healing requires both the generation of ROS to inhibit bacteria and the subsequent reduction of ROS levels to initiate and promote tissue regeneration, which calls for a more intelligent ROS regulation dressing system. Hence, a dual‐layered hydrogel (Dual‐Gel) tailored to the process of burn wound repair is designed: the inner layer hydrogel (Gel 2) first responds to bacterial hyaluronidase (Hyal) to deliver aggregation‐induced emission (AIE) photosensitizer (PS) functionalized adipose‐derived stem cell nanovesicles, which generate ROS upon light irradiation to eliminate bacteria; then the outer layer hydrogel (Gel 1) continuously starts a long‐lasting consumption of excess ROS at the wound site to accelerate tissue regeneration. Simultaneously, the stem cell nanovesicles trapped in the burns wound also provide nutrients and mobilize neighboring tissues to thoroughly assist in inflammation regulation, cell proliferation, migration and angiogenesis. In summary, this study develops an intelligent treatment approach on burn wounds by programmatically regulating ROS and facilitating comprehensive wound tissue repair.This article is protected by copyright. All rights reserved

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Harnessing antimicrobial peptide-coupled photosensitizer to combat drug-resistant biofilm infections through enhanced photodynamic therapy

Cited by 12 publications

References 47 publications

A peptide-based pH-sensitive antibacterial hydrogel for healing drug-resistant biofilm-infected diabetic wounds

A peptide-based pH-sensitive antibacterial hydrogel for healing drug-resistant biofilm-infected diabetic wounds

Spatiotemporally Controllable Bifunctional Micellar-Carbon Dot Supernanoparticles for Wounds Healing

Stem Cell‐Derived Nanovesicles Embedded in Dual‐Layered Hydrogel for Programmed ROS Regulation and Comprehensive Tissue Regeneration in Burn Wound Healing

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