Dehumanization has figured prominently in intergroup discrimination and violence, which has inspired sustained social-psychological inquiry. Over two decades, researchers have brought an abundance of theories and methods to bear on the empirical study of dehumanization. Collectively, this work has painted an expansive portrait of the many ways we can overlook or deny the humanity of others. At the same time, these diverse conceptual and measurement approaches have progressed in relative isolation, which has created confusion about what, precisely, is meant by “dehumanization” and cast uncertainty on fundamental conclusions drawn from this research. To stimulate theoretical development and more-productive exchanges across the field, we offer an integrative framework for dehumanization research. Within this Family-Resemblances framework, dehumanization is seen as a multifaceted construct that encompasses a variety of related processes with both overlapping and unique features. Thus, the diverse theoretical and methodological approaches to studying dehumanization are complementary means of capturing a fundamentally heterogeneous phenomenon. Further, we argue that this framework can catalyze a more nuanced and precise understanding of dehumanization’s many facets: by specifying the different varieties of dehumanization under investigation, the field can more precisely map them onto specific targets, causes, consequences, and intervention strategies.