The Center for Geographic Analysis (CGA) at Harvard University supports research and teaching that relies on geographic information. This includes supporting geographic analysis for public health research at Harvard. This article reviews geographic concepts that apply to public health, pertinent data available in geographic format, and GIS analytical techniques. The workflow methodology the CGA has developed for conducting research with geographic data will be presented, highlighting successful practices to follow and pitfalls to avoid. Applications of this workflow are illustrated through an in-depth discussion of specific case studies in public health research at the University.