Harnessing immunometabolism for cardiovascular health and cancer therapy

Markovska, Angela; Schipper, Henk S.; Boes, Marianne

doi:10.1093/immadv/ltab021

Cited by 4 publications

(5 citation statements)

References 15 publications

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“…The influence of a common immune-metabolic starting point on the development and progression of many diseases, including DM2 and CHD, is highly probable. [44,45] Aberrations in the transcription of a specific DNA sequence in the locus trigger a unified mechanism for the development of both diseases. The fact that immune cells adopt metabolic programs specific to their state and the surrounding environment can serve as an example of the interconnection between metabolic pathways, signaling, and cell differentiation.…”

Section: Discussionmentioning

confidence: 99%

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Evolution of the search for a common mechanism of congenital risk of coronary heart disease and type 2 diabetes mellitus in the chromosomal locus 9p21.3

Benberin,

Karabaeva,

Kulmyrzaeva

et al. 2023

Medicine

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9.21.3 chromosomal locus predisposes to coronary heart disease (CHD) and type 2 diabetes mellitus (DM2), but their overall pathological mechanism and clinical applicability remain unclear. The review uses publications of the study results of 9.21.3 chromosomal locus in association with CHD and DM2, which are important for changing the focus of clinical practice. The eligibility criteria are full-text articles published in the PubMed database (MEDLINE) up to December 31, 2022. A total of 56 publications were found that met the inclusion criteria. Using the examples of the progressive stages in understanding the role of the chromosomal locus 9p.21.3, scientific ideas were grouped, from a fragmentary study of independent pathological processes to a systematic study of the overall development of CHD and DM2. The presented review can become a source of new scientific hypotheses for further studies, the results of which can determine the general mechanism of the congenital risk of CHD and DM2 and change the focus of clinical practice.

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Section: Discussionmentioning

confidence: 99%

“…The influence of a common immune-metabolic starting point on the development and progression of many diseases, including DM2 and CHD, is highly probable. [ 44 , 45 ]…”

Section: Discussionmentioning

confidence: 99%

Evolution of the search for a common mechanism of congenital risk of coronary heart disease and type 2 diabetes mellitus in the chromosomal locus 9p21.3

Benberin,

Karabaeva,

Kulmyrzaeva

et al. 2023

Medicine

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“…Recent advances in the field of immunometabolism have paved the way for therapeutically targeting metabolic cellular reactions in order to control immunity and inflammation in a plethora of disease states such as cancer, autoimmune and infectious diseases (175)(176)(177)(178)(179)(180). As such, metabolism of immune cells may be reprogrammed to induce or suppress inflammatory reactions.…”

Section: Clinical Significancementioning

confidence: 99%

Immunometabolism – The Role of Branched-Chain Amino Acids

Yahsi

Günaydın

2022

Front. Immunol.

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Immunometabolism has been the focus of extensive research over the last years, especially in terms of augmenting anti-tumor immune responses. Regulatory T cells (Tregs) are a subset of CD4+ T cells, which have been known for their immunosuppressive roles in various conditions including anti-tumor immune responses. Even though several studies aimed to target Tregs in the tumor microenvironment (TME), such approaches generally result in the inhibition of the Tregs non-specifically, which may cause immunopathologies such as autoimmunity. Therefore, specifically targeting the Tregs in the TME would be vital in terms of achieving a successful and specific treatment. Recently, an association between Tregs and isoleucine, which represents one type of branched-chain amino acids (BCAAs), has been demonstrated. The presence of isoleucine seems to affect majorly Tregs, rather than conventional T cells. Considering the fact that Tregs bear several distinct metabolic features in the TME, targeting their immunometabolic pathways may be a rational approach. In this Review, we provide a general overview on the potential distinct metabolic features of T cells, especially focusing on BCAAs in Tregs as well as in their subtypes.

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“…The collection brought together by Marianne Boes, our Regional Editor for Europe, explored ways of harnessing immunometabolism for improved responses to vaccination and other forms of immunotherapy [ 1 ]. Other collections focus on immunotherapeutic approaches to treating allergy and asthma, cellular therapies and immune-related adverse immune responses in cancer immunotherapies.…”

mentioning

confidence: 99%

“…These compilations are typically anchored by one or two reviews from field-leaders including O’Carroll et al [ 2 ], link to at least one of our Clinical Trials Watch series of articles, e.g. Pallett et al [ 3 ] and are tied together by a short editorial overview [ 1 ]. They serve as an open-call for research papers in that area and are intended to improve the visibility and impact of all articles in the collection, as is evident from the popularity of the immunometabolism content which includes one of the most frequently accessed articles we have published so far with 6640 views [ 4 ].…”

mentioning

confidence: 99%

Immunotherapy advances: One year on

Elliott

2022

Immunotherapy Advances

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Harnessing immunometabolism for cardiovascular health and cancer therapy

Cited by 4 publications

References 15 publications

Evolution of the search for a common mechanism of congenital risk of coronary heart disease and type 2 diabetes mellitus in the chromosomal locus 9p21.3

Evolution of the search for a common mechanism of congenital risk of coronary heart disease and type 2 diabetes mellitus in the chromosomal locus 9p21.3

Immunometabolism – The Role of Branched-Chain Amino Acids

Immunotherapy advances: One year on

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