Harnessing natural product polysaccharides against lung cancer and revisit its novel mechanism

Tian, Wangqi; Huang, Jumin; Zhang, Weitong; Wang, Yifan; Jin, Ruyi; Guo, Hui; Tang, Yuping; Wang, Yuwei; Lai, Huanling; Leung, Elaine Lai-Han

doi:10.1016/j.phrs.2023.107034

Cited by 5 publications

References 122 publications

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The Sources, Structures and Cytotoxicity of Animal‐Derived Bisindole Compounds

Zhang,

Xu,

Gong

et al. 2024

Chemistry & Biodiversity

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Bisindole compounds constitute a significant class of natural compounds distinguished by their characteristic bisindole structure and renowned for their anticancer properties. Over the past four decades, researchers have isolated 229 animal‐derived bisindole compounds (ADBCs) from various animals. These compounds demonstrate a wide range of pharmacological properties, including cytotoxicity, antibacterial, antifungal, antiviral, and other activities. Notably, among these activities, cytotoxicity emerges as the most prominent characteristic of ADBCs. This review also summarizes the structureactivity relationship (SAR) studies associated with the cytotoxicity of these compounds and explores the druggability of these compounds. In summary, our objective is to provide an overview of the research progress concerning ADBCs, with the aim of fostering their continued development and utilization.

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The Sources, Structures and Cytotoxicity of Animal‐Derived Bisindole Compounds

Zhang,

Xu,

Gong

et al. 2024

Chemistry & Biodiversity

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Structural characterization and potential antitumor and immunostimulatory activities of mycelial polysaccharides from Ophiocordyceps gracilis

Tong,

Qi,

Lian

et al. 2025

Process Biochemistry

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Identification of potential core genes in lung cancer and therapeutic traditional Chinese medicine compounds using bioinformatics analysis

Zhang,

Wang,

Zhang

et al. 2024

Medicine

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Lung cancer (LC) remains the leading cause of cancer-related death. We identified potential therapeutic targets and traditional Chinese medicine (TCM) compounds for LC treatment. GSE43346 and GSE18842 were derived from the Gene Expression Omnibus (GEO) database and used to identify differentially expressed genes (DEGs). Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed using The Database for Annotation, Visualization and Integrated Discovery (DAVID). Protein–protein interactions were analyzed using STRING and Cytoscape software. Hub gene expression was validated using Gene Expression Profiling Interactive Analysis and the Human Protein Atlas. Kaplan–Meier survival analysis was conducted to evaluate the prognostic value of hub genes in patients with LC. Therapeutic TCM compounds were screened using the Comparative Toxicogenomics Database, and DEGs were largely enriched in biological processes, including cell division and mitotic nuclear division, such as the cell cycle and p53 signaling pathways. Elevated expression of hub genes was observed in LC samples. Overexpression of CDC20, CCNB2, and TOP2A is an unfavorable prognostic factor for postprogressive survival in patients with LC. Paclitaxel, quercetin, and rotenone have been identified as active substances in TCM. CDC20, CCNB2, and TOP2A are novel hub genes associated with LC. Paclitaxel, quercetin, and rotenone can be used as therapeutic agents in TCM.

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Harnessing natural product polysaccharides against lung cancer and revisit its novel mechanism

Cited by 5 publications

References 122 publications

The Sources, Structures and Cytotoxicity of Animal‐Derived Bisindole Compounds

The Sources, Structures and Cytotoxicity of Animal‐Derived Bisindole Compounds

Structural characterization and potential antitumor and immunostimulatory activities of mycelial polysaccharides from Ophiocordyceps gracilis

Identification of potential core genes in lung cancer and therapeutic traditional Chinese medicine compounds using bioinformatics analysis

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