2022
DOI: 10.1016/j.bbcan.2022.188749
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Harnessing redox signaling to overcome therapeutic-resistant cancer dormancy

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Cited by 19 publications
(10 citation statements)
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“…7 ). Redox regulates cancer drug tolerance and dormancy, which are closely related to poor prognosis [ 265 , 266 ]. Depletion of the E3 ligase FBXW7 sensitizes dormant cancer cells to paclitaxel, indicating that protein degradation may participate in the regulation of dormancy [ 267 ].…”
Section: Tumor Microenvironment Remodeling By Protein Degradation-reg...mentioning
confidence: 99%
“…7 ). Redox regulates cancer drug tolerance and dormancy, which are closely related to poor prognosis [ 265 , 266 ]. Depletion of the E3 ligase FBXW7 sensitizes dormant cancer cells to paclitaxel, indicating that protein degradation may participate in the regulation of dormancy [ 267 ].…”
Section: Tumor Microenvironment Remodeling By Protein Degradation-reg...mentioning
confidence: 99%
“…Specifically, intrinsic resistance is mainly caused by existing factors (e.g., gene mutations), while acquired resistance is caused by changes in tumor cells during treatment, including drug target expression, post-translational modification, and activation of bypass signaling ( Holohan et al, 2013 ; Li et al, 2020 ). Recent studies have shown that the stress response induced during tumor treatment, especially oxidative stress, is one of the vital reasons for the acquired drug resistance of tumor cells ( Cui et al, 2018 ; Qin et al, 2022 ).…”
Section: Introductionmentioning
confidence: 99%
“…RONS have been involved in aging and cellular senescence [8], as well as in diverse inborn [9,10] or acquired conditions, such as inflammatory [11][12][13][14] and cardiovascular diseases [15][16][17][18], thrombosis [19], cancerogenesis [20][21][22][23] and, paradoxically, anticancer chemotherapy [24], viral infections [25,26], neurodegenerative conditions [27][28][29] and metabolic syndromes [30]. On the other hand, RONS are partners in multiple intercellularand intracellular signaling [31][32][33][34] and play important roles in homeostatic processes involved both in the destruction of invading pathogens [35] or in the adaptation to endogenous and exogenous stress [36][37][38].…”
Section: Introduction: Oxygen Ros and Oxidative Stressmentioning
confidence: 99%