Harnessing the 1,3-azadiene-anhydride reaction for the regioselective and stereocontrolled synthesis of lactam-fused bromotetrahydropyrans by bromoetherification of lactam-tethered trisubstituted tertiary alkenols

Abstract

The bromoetherification of readily affordable lactam-tethered trisubstituted tertiary alkenols has facilitated the site-selective, efficient, and stereocontrolled synthesis of halogenated fused lactam-tetrahydropyrans.