Harnessing the Benefits of Endogenous Hydrogen Sulfide to Reduce Cardiovascular Disease

Casin, Kevin M.; Calvert, John W.

doi:10.3390/antiox10030383

Cited by 16 publications

(11 citation statements)

References 181 publications

(126 reference statements)

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“…From a clinical perspective, H 2 S has been posited to have a protective role against the onset and development of atherosclerosis 62 – 64 . Whereas defects in H 2 S signalling, including its synthesizing enzymes, can lead to CVD and associated complications 15 , 65 – 68 , H 2 S-based interventions have proved to be beneficial in preventing adult-onset CVD in animal studies via the reversal of disease-programming processes 69 . Plasma H 2 S levels have been shown to be significantly lower in patients with coronary heart disease than in angiographically normal control individuals 70 .…”

Section: Sulfides In the Cardiovascular Systemmentioning

confidence: 99%

Sulfide regulation of cardiovascular function in health and disease

et al. 2022

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Hydrogen sulfide (H 2 S) has emerged as a gaseous signalling molecule with crucial implications for cardiovascular health. H 2 S is involved in many biological functions, including interactions with nitric oxide, activation of molecular signalling cascades, post-translational modifications and redox regulation. Various preclinical and clinical studies have shown that H 2 S and its synthesizing enzymes — cystathionine γ-lyase, cystathionine β-synthase and 3-mercaptosulfotransferase — can protect against cardiovascular pathologies, including arrhythmias, atherosclerosis, heart failure, myocardial infarction and ischaemia–reperfusion injury. The bioavailability of H 2 S and its metabolites, such as hydropersulfides and polysulfides, is substantially reduced in cardiovascular disease and has been associated with single-nucleotide polymorphisms in H 2 S synthesis enzymes. In this Review, we highlight the role of H 2 S, its synthesizing enzymes and metabolites, their roles in the cardiovascular system, and their involvement in cardiovascular disease and associated pathologies. We also discuss the latest clinical findings from the field and outline areas for future study.

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Section: Sulfides In the Cardiovascular Systemmentioning

confidence: 99%

Sulfide regulation of cardiovascular function in health and disease

et al. 2022

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“…H 2 S concentration is an important determinant of the body's defense against disease. Dysregulation of H 2 S levels has been described in the pathogenesis of various conditions ranging from cardiovascular diseases to septic shock [ 316 , 317 ]. Reduced H 2 S levels are proposed as a contributor to the pathogenesis of asthma, and rescue with exogenous H 2 S was found to alleviate asthma severity in two separate animal models [ 318 , 319 ].…”

Section: Dysregulation Of H 2 Smentioning

confidence: 99%

Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promise

Oza¹,

Kashfi²

2022

Nitric Oxide

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“…Increasing knowledge of the biochemistry of H 2 S may be exploited for the design of dietary intervention studies aimed at augmenting antioxidant defense. Detailed reviews on the roles of H 2 S in antioxidant functions with potential clinical relevance are available [150,[152][153][154]. A review of chemical tools to study small molecule persulfides has also been published [155].…”

Section: Antioxidant Functions Of H 2 Smentioning

confidence: 99%

Biosynthesis, Quantification and Genetic Diseases of the Smallest Signaling Thiol Metabolite: Hydrogen Sulfide

et al. 2021

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Hydrogen sulfide (H2S) is a gasotransmitter and the smallest signaling thiol metabolite with important roles in human health. The turnover of H2S in humans is mainly governed by enzymes of sulfur amino acid metabolism and also by the microbiome. As is the case with other small signaling molecules, disease-promoting effects of H2S largely depend on its concentration and compartmentalization. Genetic defects that impair the biogenesis and catabolism of H2S have been described; however, a gap in knowledge remains concerning physiological steady-state concentrations of H2S and their direct clinical implications. The small size and considerable reactivity of H2S renders its quantification in biological samples an experimental challenge. A compilation of methods currently employed to quantify H2S in biological specimens is provided in this review. Substantial discrepancy exists in the concentrations of H2S determined by different techniques. Available methodologies permit end-point measurement of H2S concentration, yet no definitive protocol exists for the continuous, real-time measurement of H2S produced by its enzymatic sources. We present a summary of available animal models, monogenic diseases that impair H2S metabolism in humans including structure-function relationships of pathogenic mutations, and discuss possible approaches to overcome current limitations of study.

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Harnessing the Benefits of Endogenous Hydrogen Sulfide to Reduce Cardiovascular Disease

Cited by 16 publications

References 181 publications

Sulfide regulation of cardiovascular function in health and disease

Sulfide regulation of cardiovascular function in health and disease

Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promise

Biosynthesis, Quantification and Genetic Diseases of the Smallest Signaling Thiol Metabolite: Hydrogen Sulfide

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