Harnessing the Expression of TNFR2 on Tregs to Prevent Agvhd

Vargas, Juan Gamboa; Kanzler, Carla; Scheller, Lukas; Kreckel, Jennifer; Shaikh, Haroon; Lang, Isabell; Medler, Juliane; Anany, Mohamed A.; Steinfatt, Tim; Hartweg, Julia; Haack, Stefanie; Holler, Ernst; Büttner‐Herold, Maike; Gaviria, Paula Tabares; Wajant, Harald; Beilhack, Andreas; Einsele, Hermann

doi:10.1182/blood-2022-168592

Blood

2022

DOI: 10.1182/blood-2022-168592

|View full text |Cite

Harnessing the Expression of TNFR2 on Tregs to Prevent Agvhd

Juan Gamboa Vargas

Carla Kanzler

Lukas Scheller

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Therapeutic potential of TNFR2 agonists: a mechanistic perspective

Chen,

Jiang,

Chen

2023

Front. Immunol.

View full text Add to dashboard Cite

TNFR2 agonists have been investigated as potential therapies for inflammatory diseases due to their ability to activate and expand immunosuppressive CD4+Foxp3+ Treg cells and myeloid-derived suppressor cells (MDSCs). Despite TNFR2 being predominantly expressed in Treg cells at high levels, activated effector T cells also exhibit a certain degree of TNFR2 expression. Consequently, the role of TNFR2 signaling in coordinating immune or inflammatory responses under different pathological conditions is complex. In this review article, we analyze possible factors that may determine the therapeutic outcomes of TNFR2 agonism, including the levels of TNFR2 expression on different cell types, the biological properties of TNFR2 agonists, and disease status. Based on recent progress in the understanding of TNFR2 biology and the study of TNFR2 agonistic agents, we discuss the future direction of developing TNFR2 agonists as a therapeutic agents.

show abstract

Therapeutic potential of TNFR2 agonists: a mechanistic perspective

Chen,

Jiang,

Chen

2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Harnessing the Expression of TNFR2 on Tregs to Prevent Agvhd

Cited by 1 publication

References 0 publications

Therapeutic potential of TNFR2 agonists: a mechanistic perspective

Therapeutic potential of TNFR2 agonists: a mechanistic perspective

Contact Info

Product

Resources

About