Harnessing the Potential of Phytochemicals for Breast Cancer Treatment

Singh, Manvi; Mohapatra, Sradhanjali; Sanskriti,; Kaur, Navneet; Mushtaq, Abeeda; Zahid, Sheikh; Pandith, Arshad A.; Mansoor, Sheikh; Iqbal, Zeenat

doi:10.1007/978-3-030-72999-8_12

Cited by 7 publications

(2 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Menopausal hormonal therapy (MHT) is one of the most successful treatment options for the mitigation of postmenopausal syndrome and related complications. Other non‐hormonal choices include low‐dose antidepressants, serotonin and norepinephrine reuptake inhibitors, and Gabapentin, but none come up without the side effects and other pharmaco‐technical limitations (Singh et al, 2021). Selective estrogen receptor modulators (SERMs) are also used to minimize these problems.…”

Section: Introductionmentioning

confidence: 99%

Phytotherapeutic approach for conquering menopausal syndrome and osteoporosis

Mohapatra,

Kumar,

Aggarwal

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

Women face a significant change in their reproductive health as menopause sets in. It is marred with numerous physiological changes that negatively impact their quality of life. This universal, transition phase is associated with menopausal and postmenopausal syndrome, which may spread over 2–10 years. This creates a depletion of female hormones causing physical, mental, sexual and social problems and may, later on, manifest as postmenopausal osteoporosis leading to weak bones, causing fractures and ultimately morbidity and mortality. Menopausal hormone therapy generally encompasses the correction of hormone balance through various pharmacological agents, but the associated side effects often lead to cessation of therapy with poor clinical outcomes. However, it has been noticed that phytotherapeutics is trusted by women for the amelioration of symptoms related to menopause and for improving bone health. This could primarily be due to their reduced side effects and lesser costs. This review attempts to bring forth the suitability of phytotherapeutics/herbals for the management of menopausal, postmenopausal syndrome, and menopausal osteoporosis through several published research. It tries to enlist the available botanicals with their key constituents and mechanism of action for mitigating symptoms associated with menopause as well as osteoporosis. It also includes a list of a few herbal commercial products available for these complications. The article also intends to collate the findings of various clinical trials and patents available in this field and provide a window for newer research avenues in this highly important yet ignored health segment.

show abstract

Section: Introductionmentioning

confidence: 99%

Phytotherapeutic approach for conquering menopausal syndrome and osteoporosis

Mohapatra,

Kumar,

Aggarwal

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Although, there is easy availability of pharmacological interventions like hormone replacement therapy (HRT) and other suitable agents to manage associated symptoms of menopause, but there is substantial apprehension in subjects for its usage due to adverse effects linked with long-term therapy. Alternatively, phytoestrogens, which majorly mimic the estrogenic effect can be consumed but albeit with troublesome effects on prolonged use [ 3 ]. Furthermore, botanicals when consumed orally may pose an unnecessary burden on the liver and could be detrimental to health [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Quality by Design Assisted Optimization and Risk Assessment of Black Cohosh Loaded Ethosomal Gel for Menopause: Investigating Different Formulation and Process Variables

et al. 2023

View full text Add to dashboard Cite

Black cohosh (Cimicifuga racemosa) (CR) is a popular herb and is medically lauded for ameliorating myriad symptoms associated with menopause. However, its pharmaceutical limitations and non-availability of a patient-compliant drug delivery approach have precluded its prevalent use. Henceforth, the current research premise is aimed at developing an ethosomal gel incorporating triterpene enriched fraction (TEF) obtained from CR and evaluating its effectiveness through the transdermal application. TEF-loaded ethosomes were formulated using solvent injection, optimized and characterised. The optimized ethosomes were then dispersed into a polymeric gel base to form ethosomal gel which was further compared with the conventional gel by in-vitro and ex-vivo experiments. Here, the quality by design (QbD) approach was exploited for the optimization and development of ethosomal gel. The elements of QbD comprising initial risk assessment, design of experimentation (DoE), and model validation for the development of formulation have all been described in detail. The optimized ethosomes (F03) showed a nanometric size range, negative zeta potential and good entrapment. The in vitro release profile of gel revealed a burst release pattern following the Korsmeyer Peppas model having Fickian diffusion. The transdermal flux of ethosomal gel was observed to be more than that of conventional gel. Texture analysis and rheological characterization of the gel, revealed good strength showing shear thinning and pseudoplastic behaviour. The confocal microscope investigation revealed the deeper skin permeation of ethosomal gel than conventional gel. This result was further strengthened by DSC, IR and histological assessment of the animal skin (Wistar rat), treated with the optimized formulation. Conclusively, the implementation of QbD in the formulation resulted in a better understanding of the process and the product. It aids in the reduction of product variability and defects, hence improving product development efficiencies. Additionally, the ethosomal gel was found to be a more effective and successful carrier for TEF than the conventional gel through the transdermal route. Moreover, this demands an appropriate animal study, which is underway, for a stronger outcome.

show abstract