Harnessing the power of gold: advancements in anticancer gold complexes and their functionalized nanoparticles

Abstract

Captivating anticancer properties of gold complexes and functionalized gold nanoparticles.

Use of Biomaterials in 3D Printing as a Solution to Microbial Infections in Arthroplasty and Osseous Reconstruction

“…Indeed, the antimicrobial potential of metal nanoparticles has been studied in detail by numerous researchers (e.g., [ 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 ]). Based on recent evidence, metal nanoparticles may also have an important role to play in the diagnosis and even treatment of cancer [ 270 , 271 ]; this can be important in cases of bone degeneration and even fracturing due to cancer [ 272 , 273 ]. A typical example is the case of osteosarcoma, a primary bone malignancy [ 274 , 275 ] where sometimes the only therapeutical avenues include allografting and autografting along with metallic prostheses [ 276 ].…”

Bonding states of gold/silver plasmonic nanostructures and sulfur-containing active biological ingredients in biomedical applications: a review

“…Besides the nanostructures already introduced, regular AuNPs, 107 AuNRs, 108 AuNSts, Au nanoshells (AuNSs), 109 Au nanocages (GNCs), 52 and AuNCs 97 can be used as therapeutic agents. Metalloid gold clusters with thiol protection exhibit a denser outer shell, displaying that this form is characterized by specific motifs–SL–(Au–SL–) n ( n 1/4 ), in addition to the various “classes” of configurations of the Au atoms within the core of the cluster (fcc, icosahedral, etc.…”

Interaction of Au(iii) with amino acids: a vade mecum for medicinal chemistry and nanotechnology

“…Amino acids, the basic building blocks of proteins, interact with Au( iii ) 1,2 to determine the pharmacological profile of Au( iii ) drugs, 3–9 and trigger the protein-assisted synthesis of gold nanoclusters (AuNCs). 10–14…”

“…3–9,15–22 On the one hand, there is evidence suggesting that rather than nucleic acids some specific protein targets primarily mediate the biological effects of Au( iii ) compounds. 3–9,15–24 On the other hand, the cytotoxic activity of some Au( iii ) compounds exploit metalation and inactivation of a few key intracellular proteins that are effective cancer targets. 3–9,15–23,25…”

“…3–9,15–24 On the other hand, the cytotoxic activity of some Au( iii ) compounds exploit metalation and inactivation of a few key intracellular proteins that are effective cancer targets. 3–9,15–23,25…”