Harnessing the properties of cobalt coordination complexes for biological application

Investigation of Cobalt(III)‐Tetrachlorocatechol Complexes as Models for Catechol‐Based Anticancer Prodrugs

“…If reduction takes place in the oxygen‐rich environment of a healthy tissue, the original cobalt(III) compound is regenerated by oxidation by O 2 . Nonetheless, under hypoxic conditions, the reduced cobalt(II) complex remains in its labile form long enough to undergo dissociation, releasing the drug in its active form to attack the nearby cells , . One of the main advantages of this strategy is the increase of the local therapeutic concentration of the drug inside the tumor, reducing side effects by decreasing the exposure of normal cells to high concentrations of the active drug .…”

“…Nonetheless, under hypoxic conditions, the reduced cobalt(II) complex remains in its labile form long enough to undergo dissociation, releasing the drug in its active form to attack the nearby cells , . One of the main advantages of this strategy is the increase of the local therapeutic concentration of the drug inside the tumor, reducing side effects by decreasing the exposure of normal cells to high concentrations of the active drug . The presence of two adjacent positions that allows a bidentate coordination of the donor atoms (typically oxygen or nitrogen) of the drug (or drug model) to the cobalt(III) center is usually required to obtain a stable prodrug .…”

“…[6,7] One of the main advantages of this strategy is the increase of the local therapeutic concentration of the drug inside the tumor, reducing side effects by decreasing the exposure of normal cells to high concentrations of the active drug. [1][2][3][4][5][6][7] The presence of two adjacent positions that allows a bidentate coordination of the donor atoms (typically oxygen or nitrogen) of the drug (or drug model) to the cobalt(III) center is usually required to obtain a stable prodrug. [6] Thus, ortho-diphenol (or catechol) derivatives are potential candidates for the cobalt-prodrug strategy due to a variety of pharmacological properties, including antioxidant, neuroprotective, anti-inflammatory and antitumor.…”

Theoretical and experimental investigation of anticancer activities of an acyclic and symmetrical compartmental Schiff base ligand and its Co(ii), Cu(ii) and Zn(ii) complexes

“…In addition to the expected biological properties of the Schiff base compounds, [30][31][32][33][34][35] binding the cobalt, copper and zinc atoms to this unit make these complexes a good prospect for biologically active compounds [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] (31)(32)(33)(34)(35) for zinc, 36-40 for cobalt, 41-45 for copper). For the study of the biological activities of new ligand (H 3 L Br ) and its complexes 1-3, docking calculations were run to investigate the possibility of interaction between these compounds with nine protein targets, including: BRAF kinase, cathepsin B (CatB), DNA gyrase, histone deacetylase (HDAC7), recombinant human albumin (rHA), ribonucleotide reductases (RNR), thioredoxin reductase (TrxR), thymidylate synthase (TS), topoisomerase II (Top II).…”

Multi-genomic analysis of the Cation Diffusion Facilitator transporters from algae

“…Zn is an important co-factor for many enzymes, such as carbonic anhydrase that is required for photosynthetic carbon fixation, and is associated with many Zn-finger containing transcription factors, and has a structural role with some proteins (Decaria et al 2010;Hänsch and Mendel 2009). Co is an essential metal in a few organisms, such as where it is required for vitamin B12 and used by coenzyme B12dependent enzymes (Renfrew et al 2018). Mn also has many essential enzyme co-factor requirements, such as Mn-dependent superoxide dismutase and the water splitting oxygen evolution process of Photosystem II (Pittman 2005;Socha and Guerinot 2014).…”