Harnröhrenstrikturrate nach Bestrahlung eines Prostatakarzinoms

Abstract

Urethral strictures after prostate cancer radiotherapy should be diagnosed and treated in time for long-term preservation of renal function. The rate of radiogenic urethral strictures (3.4%) is equivalent to those after radical prostatectomy. Due to a high rate of recurrences, urethrotomy has a limited importance after irradiation.

Urological complications after radiation therapy—nothing ventured, nothing gained: a Narrative Review

“…Urethral stricture is a serious complication that can lead to voiding dysfunction and, as a consequence, damage to the upper urinary tract ( 215 ). Most often, the narrowing is caused by radiation therapy for prostate cancer ( 6 , 12 ).…”

“…The overall incidence of urethral strictures after radiotherapy for prostate cancer is 2.2%, of which 1.5% after external beam radiotherapy, 1.9% after brachytherapy, and 4.9% after combination therapy ( 6 , 217 , 218 ). They are usually observed within 1–3 years after treatment ( 215 , 217 , 219 , 220 ). More than 90% of strictures are located in the bulbomembranous urethra, but this phenomenon remains unclear because this area receives a lower dose of radiation than the prostate urethra ( 6 , 215 , 217 , 220 , 221 ).…”

“…They are usually observed within 1–3 years after treatment ( 215 , 217 , 219 , 220 ). More than 90% of strictures are located in the bulbomembranous urethra, but this phenomenon remains unclear because this area receives a lower dose of radiation than the prostate urethra ( 6 , 215 , 217 , 220 , 221 ). The median stenosis length is between 1 and 3.5 cm ( 215 , 222 - 224 ).…”

Posterior urethral stenosis after prostate cancer treatment: contemporary options for definitive management

“…The prevalence of anastomotic stenosis after RP ranges from 4.8–8.4% ( 3 , 16 ) and 0.2–5.5% following robotic assisted laparoscopic radical prostatectomy (RALP) ( 4 , 5 , 7 ). Following EBRT alone 2–4% developed new strictures ( 3 , 10 ). Brachytherapy, especially in combination with EBRT, resulted in higher rate of 5–12% ( 8 , 10 , 17 ).…”

“…Following EBRT alone 2–4% developed new strictures ( 3 , 10 ). Brachytherapy, especially in combination with EBRT, resulted in higher rate of 5–12% ( 8 , 10 , 17 ). In a recent meta-analysis of 5,849 patients undergoing brachytherapy (BT), the pooled prevalence of strictures after brachytherapy is estimated at 1.9% (95% CI: 1.3–2.4%) (AWAD).…”