Harris lines revisited: Prevalence, comorbidities, and possible etiologies

Papageorgopoulou, Christina; Suter, Susanne K.; Rühli, Frank J; Siegmund, Frank

doi:10.1002/ajhb.21155

Cited by 75 publications

(50 citation statements)

References 60 publications

(102 reference statements)

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“…As bone growth continues at the growth plate, growth arrest lines migrate to the diaphysis. Such lines change with bone remodeling and can disappear completely with time [11].…”

Section: Discussionmentioning

confidence: 99%

Growth Arrest Line Mimicking Lymphoma Involvement: The Findings of 99mTc-MDP Bone SPECT/CT and Serial Bone Scan in a Child with Non-Hodgkin’s Lymphoma

Kim

Choi

et al. 2016

Nucl Med Mol Imaging

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Growth arrest lines appear as dense sclerotic lines parallel to the growth plate of long bones on radiography. We describe the case of a 9-year-old female with growth arrest lines initially masquerading as lymphoma involvement on 99m Tc-MDP bone scintigraphy who had been treated with chemotherapy for non-Hodgkin's lymphoma about 3 years previously. Subsequent regional bone SPECT/CT clearly diagnosed the growth arrest lines, and retrograde review of previous bone scintigraphy demonstrated line migration in this patient. Growth arrest lines should be considered a possible diagnosis on bone scintigraphy, especially in the surveillance of children who have experienced severe childhood infections, malnutrition, immobilization, or treatment with immunosuppressive or chemotherapeutic drugs that may inhibit bone growth.

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“…As bone growth continues at the growth plate, growth arrest lines migrate to the diaphysis. Such lines change with bone remodeling and can disappear completely with time [11].…”

Section: Discussionmentioning

confidence: 99%

Growth Arrest Line Mimicking Lymphoma Involvement: The Findings of 99mTc-MDP Bone SPECT/CT and Serial Bone Scan in a Child with Non-Hodgkin’s Lymphoma

Kim

Choi

et al. 2016

Nucl Med Mol Imaging

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“…The absence of Harris lines suggest that there are other factors responsible for their occurrence than those causing the formation of stress markings in the microstructure of teeth. However, it is possible that Harris lines are more likely a result of normal growth and growth spurts, rather than a pure outcome of nutritional or pathologic stress (Papageorgopoulou et al 2011). Cribra orbitalia indicates that this individual experienced some kind of chronic health problem, not necessarily anemia (Wapler -Crubézy -Schultz 2004), but they are only slightly expressed and pseudopathology cannot be excluded without histological examination.…”

Section: Poděkovánímentioning

confidence: 97%

“…Nepřítomnost Harrisových linií na rentgenových snímcích dlouhých kostí naznaču-je, že vznikají pod vlivem jiných faktorů, než které souvisí se vznikem stresových markerů v mikrostruktuře zubů. Také je možné, že jsou projevem normálního růstu a růstového spurtu spíše než nutričního nebo patologického stresu (Papageorgopoulou et al 2011). Ohledně náznaku cribra orbitalia v pravé očnici, histologická analýza kostní tkáně by mohla přinést informace o tom, zda jde skutečně o indikaci zhoršeného zdravotního stavu (nejen z důvodu anémie, jelikož etiologie cribra orbitalia je stále nejasná) nebo jen o postmortální změny a tedy pseudopatologii (Wapler -Crubézy -Schultz 2004).…”

Section: čAsování Stresových Událostíunclassified

Nejsou čáry jako čáry: inkrementální linie v mikrostruktuře zubů a jejich využití při analýze kosterních nálezů

Hupková¹,

Šáliová²,

Králík³

et al. 2016

Studia Archaeologica Brunensia

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AbstraktBuňky produkující tvrdé zubní tkáně zanechávají v průběhu vývoje zubů pod vlivem různých metabolických rytmů záznam o jejich aktivitě ve formě růstových markerů, označovaných jako inkrementální linie. Kromě těchto pravidelných časových markerů jsou v mikrostruktuře zubů zaznamenaná a po celou dobu existence zubu přítomná také metabolická a fyziologická narušení způsobená stresovými událostmi. Cílem tohoto příspěvku je rekonstrukce vývojového záznamu ze zubů kosterního nálezu dítěte z ojedinělého hrobu na lokalitě Muráň-Hrad, Slovensko pomocí metody odontochronologie a také načrtnutí možných přínosů využití histologického přístupu a analýz výbrusů zubů v bioarcheologii při studiu minulých populací. Klíčová slovaodontochronologie, histologie tvrdých zubních tkání, vývoj zubů, stres, akcentované linie, dožitý věk (chronologický) AbstractDuring the period of formation of the teeth, the cells that secrete dental hard tissues under various metabolic rhythms leave a record of their activity in the form of growth markers called incremental lines. Besides these regular time markers, in the microstructure of teeth metabolic and physiological disturbances caused by stressful events are permanently recorded and observable for as long as the tooth exists. The purpose of the present study was to apply odontochronological techniques in retrieval of a developmental record from dental remains of a child's skeleton from a solitary burial found in a site Muráň-Castle, Slovakia and to outline how bioarchaeology can beneficiate by including the histological approach and analysis of tooth sections in the study of past populations. Keywordsodontochronology, dental hard tissue histology, dental development, stress, accentuated lines, (chronological) age at death Příspěvek vznikl díky podpoře specifického výzkumu "Aplikace metod analýzy obrazu a tvaru v rutinním zpracování kosterních nálezů" (MUNI/A/0835/2012) a "Bioarcheologické metody pro komplexní hodnocení raně středověkých populací" (MUNI/A/0983/2013).

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“…When endochondral ossification resumes, the dense mineralized line moves away from the physis [41,42]. We hypothesize that the frequent occurrence of Harris lines in XLH (89%) may be related to periods in which the treatment is less than optimal.…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging Features as Surrogate Markers of X-Linked Hypophosphatemic Rickets Activity

Lempicki¹,

Rothenbühler²,

Merzoug³

et al. 2017

Horm Res Paediatr

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Objective: X-linked hypophosphatemic rickets (XLH) is the most common form of inheritable rickets. Rickets treatment is monitored by assessing alkaline phosphatase (ALP) levels, clinical features, and radiographs. Our objectives were to describe the magnetic resonance imaging (MRI) features of XLH and to assess correlations with disease activity. Study Design: Twenty-seven XLH patients (median age 9.2 years) were included in this prospective single-center observational study. XLH activity was assessed using height, leg bowing, dental abscess history, and serum ALP levels. We looked for correlations between MRI features and markers of disease activity. Results: On MRI, the median maximum width of the physis was 5.6 mm (range 4.8-7.8; normal <1.5), being >1.5 mm in all of the patients. The appearance of the zone of provisional calcification was abnormal on 21 MRI images (78%), Harris lines were present on 24 (89%), and bone marrow signal abnormalities were present on 16 (59%). ALP levels correlated with the maximum physeal widening and with the transverse extent of the widening. Conclusions: MRI of the knee provides precise rickets patterns that are correlated with ALP, an established biochemical marker of the disease, avoiding X-ray exposure and providing surrogate quantitative markers of disease activity.

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Harris lines revisited: Prevalence, comorbidities, and possible etiologies

Abstract: We suggest a reconsideration of HLs as more of a result of normal growth and growth spurts, rather than a pure outcome of nutritional or pathologic stress.

Cited by 75 publications

References 60 publications

Growth Arrest Line Mimicking Lymphoma Involvement: The Findings of 99mTc-MDP Bone SPECT/CT and Serial Bone Scan in a Child with Non-Hodgkin’s Lymphoma

Growth Arrest Line Mimicking Lymphoma Involvement: The Findings of 99mTc-MDP Bone SPECT/CT and Serial Bone Scan in a Child with Non-Hodgkin’s Lymphoma

Nejsou čáry jako čáry: inkrementální linie v mikrostruktuře zubů a jejich využití při analýze kosterních nálezů

Magnetic Resonance Imaging Features as Surrogate Markers of X-Linked Hypophosphatemic Rickets Activity

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