Harveian Oration 2017: Triumphs and challenges in a world shaped by medicine

Whitty, Christopher J. M.

doi:10.7861/clinmedicine.17-6-537

Cited by 31 publications

(20 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In order to make the findings generalizable in other settings, we used categories of long‐term conditions as our exposures, although an alternative would have been to examine associations with individual conditions. Finally, an area for future work would be to explore if particular clusters of categories have stronger associations with sarcopenia than suggested by their individual associations …”

Section: Discussionmentioning

confidence: 99%

Sarcopenia, long‐term conditions, and multimorbidity: findings from UK Biobank participants

Dodds

Granic

Robinson

et al. 2019

J cachexia sarcopenia muscle

107

View full text Add to dashboard Cite

Background Sarcopenia, the loss of muscle strength and mass, predicts adverse outcomes and becomes common with age. There is recognition that sarcopenia may occur at younger ages in those with long‐term conditions (LTCs) as well as those with multimorbidity (the presence of two or more LTCs), but their relationships have been little explored. Our aims were to describe the prevalence of sarcopenia in UK Biobank, a large sample of men and women aged 40–70 years, and to explore relationships with different categories of LTCs and multimorbidity. Methods We used data from 499 046 participants in the baseline of UK Biobank. Our main outcome was probable sarcopenia based on maximum grip strength below sex‐specific cut‐points. Participants' LTCs were recorded during an interview and categorized against a hierarchy. We used logistic regression to examine the independent associations between each category of LTCs and probable sarcopenia, including adjustment for age, sex, and body mass index. We also examined the association with multimorbidity. Results Probable sarcopenia had an overall prevalence of 5.3% and increased with age. The categories with the strongest associations with probable sarcopenia were musculoskeletal/trauma [OR 2.17 (95% CI: 2.11, 2.23)], endocrine/diabetes [OR 1.49 (95% CI: 1.45, 1.55)], and neurological/psychiatric [OR 1.39 (95% CI: 1.34, 1.43)] LTCs. Almost half of the sample (44.5%) had multimorbidity, and they were at nearly twice the odds of probable sarcopenia [OR 1.96 (95% CI: 1.91, 2.02)] compared with those without. Conclusions We have shown an overall prevalence of 5.3% of probable sarcopenia at ages 40–70 in UK Biobank. The risk of probable sarcopenia was higher in those with some categories of LTCs, suggesting that these groups may stand to benefit from assessment of sarcopenia, during mid‐life as well as old age.

show abstract

Section: Discussionmentioning

confidence: 99%

Sarcopenia, long‐term conditions, and multimorbidity: findings from UK Biobank participants

Dodds

Granic

Robinson

et al. 2019

J cachexia sarcopenia muscle

107

View full text Add to dashboard Cite

show abstract

“…Impressive advances over the past 60 years in diagnosis, understanding disease processes, and the development of new medical, surgical and other therapies have dramatically enhanced individual health and significantly improved the quality and duration of life of all globally (Le Fanu, 2001;Pinker, 2018;Rosling, 2018;Whitty, 2017). Many, if not most of these changes have also been influenced by increases in wealth and expenditure on health care.…”

Section: Introductionmentioning

confidence: 99%

Disconnections between medical education and medical practice: A neglected dilemma

Benatar

Daneman

2020

Global Public Health

View full text Add to dashboard Cite

Medical practice has changed profoundly over the past 60 years. Many changes have also been made in medical education, often with a view to countering adverse aspects of highly specialised, commercialised and bureaucratised modern medical practice. Regardless of the state of the world today and of the variety of changes that may occur in the years ahead, excellence in the application of bedside skills and technological advances, accompanied by excellence in humanistic aspects of caring for patients as people, will remain preeminent goals at the heart of medical practice. Powerful social forces that negatively influence practice cannot be counteracted through changes in medical education alone and need to be addressed directly within health systems. Shifting healthcare towards a valued social service is arguably essential for improving both public and individual health through more widespread universal access to high quality and effectively integrated health care. ARTICLE HISTORY

show abstract

“…We also face new challenges. Improvements in living conditions and healthcare have resulted in a much greater life expectancy so, while we celebrate that, we also need to address the consequences including how we might research and provide healthcare and social care for people with increasing multimorbidity (Whitty, 2017) and a pensions crisis, the scale of which Booth could not have foreseen when he argued for the introduction of old age pensions. An area that our founders did not consider is the environment.…”

Section: The Royal Statistical Society At 200mentioning

confidence: 99%

Pigeonholes and Mustard Seeds: Growing Capacity to use Data for Society

Ashby

2019

Journal of the Royal Statistical Society Series A: Statistics in Society

View full text Add to dashboard Cite

Summary The Royal Statistical Society was founded to address social problems ‘through the collection and classification of facts’, leading to many developments in the collection of data, the development of methods for analysing them and the development of statistics as a profession. Nearly 200 years later an explosion in computational power has led, in turn, to an explosion in data. We outline the challenges and the actions needed to exploit those data for the public good, and to address the step change in statistical skills and capacity development necessary to enable our vision of a world where data are at the heart of understanding and decision making.

show abstract

Harveian Oration 2017: Triumphs and challenges in a world shaped by medicine

Cited by 31 publications

References 16 publications

Sarcopenia, long‐term conditions, and multimorbidity: findings from UK Biobank participants

Sarcopenia, long‐term conditions, and multimorbidity: findings from UK Biobank participants

Disconnections between medical education and medical practice: A neglected dilemma

Pigeonholes and Mustard Seeds: Growing Capacity to use Data for Society

Contact Info

Product

Resources

About