Hashimoto's thyroiditis and papillary thyroid cancer: polyglandular hints

Mintziori, Gesthimani; Adamidou, Fotini; Kita, Marina

doi:10.1016/j.tem.2015.05.009

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…Hashimoto's thyroiditis is the most common autoimmune disease, and its prevalence has also increased in recent years [9,12]. In the past decade, the increasing incidence of thyroid cancer together with the simultaneously increasing incidence of Hashimoto's thyroiditis leads to the question whether Hashimoto's thyroiditis is associated with thyroid cancer [22,[29][30][31]. Though many observational studies were published to assess the association between Hashimoto's thyroiditis and thyroid cancer, many studies recruited patients receiving fine-needle aspiration biopsy (FNAB) or those patients with histologically confirmed PTMC and might have high risk of selection bias [32].…”

Section: Discussionmentioning

confidence: 99%

Hashimoto’s Thyroiditis is an Important Risk Factor of Papillary Thyroid Microcarcinoma in Younger Adults

Liu

Zhao

et al. 2017

Horm Metab Res

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The association between autoimmune thyroid disease and thyroid cancer remains unclear. We performed a matched case-control study to assess the association between Hashimoto's thyroiditis and papillary thyroid microcarcinoma (PTMC). A total of 927 PTMC cases and 927 age- and gender- matched controls selected from the same population were recruited. Odds ratio (OR) with 95% confidence interval (95% CI) was used to assess the strength of the association between Hashimoto's thyroiditis and PTMC. Conditional logistic regression analysis was carried out, and stratified analyses by age, gender and types of thyroid antibodies were also performed. Hashimoto's thyroiditis was significantly associated with increased risk of PTMC (OR=1.87, 95% CI 1.49-2.34, p<0.001). Stratified analysis by thyroid antibodies also found obvious associations of PTMC risk with TPOAb positivity (OR=1.58, p=0.001) and TGAb positivity (OR=2.35, p<0.001). Stratified analyses by age showed that the association between Hashimoto's thyroiditis and PTMC risk was more significant in younger adults aged between 18 and 30 years (OR=11.48, p<0.001). Further stratified analyses by thyroid antibodies also found that the associations of PTMC risk with TPOAb positivity or TGAb positivity were more significant in younger adults aged between 18 and 30, and the ORs were 8.27 (p<0.001) and 12.71 (p<0.001), respectively. This study suggests an obvious relationship between Hashimoto's thyroiditis and PTMC risk, and Hashimoto's thyroiditis is an important risk of PTMC in younger adults.

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Section: Discussionmentioning

confidence: 99%

Hashimoto’s Thyroiditis is an Important Risk Factor of Papillary Thyroid Microcarcinoma in Younger Adults

Liu

Zhao

et al. 2017

Horm Metab Res

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“…alınan guatrojenler de TSH uyarısına neden olarak tiroid kanseri riskinde artışa yol açmaktadır. Preklinik çalışmalarda da uzun süren iyot eksikliği ile beslenen hayvanlarda, başlangıçta folliüler hiperplazi gelişimini sırasıyla nodül ve adenom oluşumu izlemiştir 12 daha sık görülmekle beraber, eğer iyot profilaksisi uygulanırsa bu ilişki tersine dönmektedir 13 . PTK olgularımızda TSH ve serbest T4 değerleri daha düşük izlenmiş, serbest T3 değeri ise kontrol grubuna göre daha yüksekti (p=0,01, p=0,09 ve p<0,001, sırasıyla).…”

Section: çAlışma Için İstanbul Medeniyet üNiversitesi Göztepeunclassified

Relationship Between Papillary Thyroid Cancer And Hashimoto's Disease

Erdoğmuş¹,

Takır²,

Köstek³

et al. 2016

MMJ

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GİrİşTiroid bezinin neden olduğu hastalıklar günümüzde dünyada ve özellikle endemik guatr bölgesi olması nedeniyle ülkemizde çok sık görülen hastalıklar ara-sında yer almaktadır. Tiroid hastalıkları klinikte sıklık sırasına göre hipotiroidizm, hipertiroidizm, endemik guatr, tiroidit, ötiroid diffüz guatr ve tiroid kanserleri olmak üzere geniş bir hastalık grubu ile karşımıza gelmektedir 1 .aBSTRaCT Thyroid cancer is the most frequent type of endocrine system cancers. Papillary thyroid carcinomas (PTCs) which have favourable prognosis and account for 80% of thyroid cancer. Hashimoto thyroiditis is the most common cause of hypothroidism in the world. Previous studies demonstrated that chronic inflammation might lead to development of cancer. This paper aimed to determine possible relationship between PTC and Hashimoto's thyroditis. Pathology archives of the patients who had been followed up with the diagnosis of thyroid papillary tumors by clinics of endocrinology, and family medicine, and undergone thyroidectomy between January 2008 and March 2015 were retrospectively reviewed. Patients under 18 years of age were not included in the study the incidence of Hashimoto thyroiditis which accompanied papillary thyroid cancer was retrospectively investigated. PTC and healthy control groups with their pathologic and laboratory data were included in the study. A total of 87 PTC and 87 healthy subjects were enrolled. Of all participants, mean age was 47±15 years and male to female ratio was approximately 1:8. in both groups. Family histories regarding thyroid carcinomas, nonthyroidal malignancies, Hashimoto thyroiditis and systematic autoimmune disease revealed similar incidence rates in both groups (p>0.05, for all). Although PTC patients had higher TSH and fT3 median values, while fT4, anti-TPO, anti-Tg values were similar. Finally, association between PTC and Hashimoto thyroiditis was analyzed, and frequency of Hashimoto thyroiditis in PTC patients, and the control group was comparable. The distribution of Hashimoto thyroiditis in patients with PTC was similar to those of the control group. öZ Tiroid kanserleri en sık görülen endokrin sistem kanserleridir. Papiller tiroid karsinomları, tiroid kanserlerinin yaklaşık %80'inini oluşturmaktadır ve en iyi prognozlu tipidir. Hashimoto tiroiditi ise dünyada en sık görülen otoimmun tiroidittir ve hipotiroidizmin en sık nedenidir. Daha önce yapılan çalışmalarda, kronik inflamasyonun kansere yol açabileceği gösterilmiştir. Çalışmamızın amacı, papiller tiroid karsinomunu ile Hashimoto tiroiditi arasında bir ilişki varlığını araştırmaktır. Endokrinoloji ve aile hekimliği kliniklerinden Ocak 2008 ve Mart 2015 tarihleri arasında tiroid papiller karsinomu (PTK) nedeniyle takip edilip, patoloji arşivleri incelenerek tiroidektomi yapılan hastalar tarandı. Yaşı 18'in altında olan hastalar çalışmaya dâhil edilmedi. Retrospektif incelemede, papiller tiroid kanserli hastalara eşlik eden Hashimoto tiroiditi sıklığı araştırıldı. Çalışmaya 87 PTK olgusu ve kontrol grubu olarak aynı sayıda 87 ki...

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