Hashimoto's Thyroiditis and Papillary Thyroid Carcinoma: Is There a Correlation?

Janković, Bojana; Le, Karen T.; Hershman, Jerome M.

doi:10.1210/jc.2012-2978

Cited by 248 publications

(205 citation statements)

References 37 publications

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“…As recently underlined by Fiore et al in their review [16], different degrees of association were found if cytological or histological series were considered [18][19][20]. As hypothesized by the Authors themselves [19], this result could be strongly influenced by a selection bias: if cytological examination is usually performed in patients with ultrasound suspicious thyroid nodules (i.e.…”

Section: Thyroid Cancer and Autoimmunity: Epidemiological And Clinicamentioning

confidence: 97%

“…As hypothesized by the Authors themselves [19], this result could be strongly influenced by a selection bias: if cytological examination is usually performed in patients with ultrasound suspicious thyroid nodules (i.e. with high a priori probability of malignancy), thyroidectomy, instead, is frequently performed in patients with GD (to treat hyperthyroidism) or due to compressive symptoms in subjects with large nodular goiter and coexisting AITD.…”

Section: Thyroid Cancer and Autoimmunity: Epidemiological And Clinicamentioning

confidence: 99%

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Thyroid Autoimmunity and Cancer

Felicetti¹,

Catalano²,

Fortunati³

2017

Frontiers of Hormone Research

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Cancer and autoimmune diseases are often associated in the same individual. The functional link between immune system and cancer development is only partially known. Even though the immune system can control the development of cancer through immune surveillance, cancer cell itself can escape immune surveillance. Actually, it is debated whether autoimmune diseases have to be regarded as cancer cause or its consequence.In particular, autoimmune thyroiditis and thyroid cancer (in particular, papillary thyroid cancer) are a fascinating model of this complex relationship. In the present review, we describe what has been reported by now in literature about autoimmune thyroiditis and papillary thyroid cancer, and on the basis of available data, we try to clarify the present knowledge.

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Section: Thyroid Cancer and Autoimmunity: Epidemiological And Clinicamentioning

confidence: 97%

Section: Thyroid Cancer and Autoimmunity: Epidemiological And Clinicamentioning

confidence: 99%

Thyroid Autoimmunity and Cancer

Felicetti¹,

Catalano²,

Fortunati³

2017

Frontiers of Hormone Research

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“…Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disorder. Hallmark of HT is the progressive loss of thyroid epithelial cells that are replaced by an infiltration of mononuclear cells (T cells) that eventually leads to thyroid atrophy and hypothyroidism (Caturegli et al 2013, Jankovic et al 2013.…”

Section: Thyroiditis and Thyroid Cancermentioning

confidence: 99%

“…On the basis of FNA studies including over 18 000 patients, the prevalence of PTC in HT is estimated to about 1.2% with a non-significant risk ratio (RR) of 0.69. In contrast, prevalence of PTC in HT based on about 10 000 archival thyroid specimens is 27% (RR 1.59; Ott et al 1987, Kashima et al 1998, Loh et al 1999, Kebebew et al 2001, Jankovic et al 2013. Thus, limiting the analysis to archival thyroidectomy specimens might carry a selection bias because the indication for surgery is commonly due to the presence of suspicious nodules.…”

Section: Thyroiditis and Thyroid Cancermentioning

confidence: 99%

Lymphocytes and thyroid cancer: more to it than meets the eye?

Weber

2014

Endocrine-Related Cancer

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Immune responses by innate and adaptive immune cells are crucial for the suppression of carcinogenesis and tumor spread. Effector T cells such as, cytotoxic CD8C T (CTL), natural killer (NK), and NK T cells (NKT cells) prevent tumor growth by their ability to induce apoptosis in cancer cells. To circumvent anti-tumor immunity, tumors commonly attract regulatory T cells (Treg), which suppress the function of CTL and NKT cells in a contact-and cytokine-dependent manner. Recent findings in patients with thyroid cancer have suggested that an imbalance between immune suppressive and anti-tumor cells occurs during thyroid carcinogenesis. However, the composition and regulation of immune responses in thyroid cancer are still elusive and a comprehensive immune profile of thyroid cancer is missing. In this issue of Endocrine-Related Cancer, Imam et al. compare immune profiles between patients with papillary thyroid carcinoma and autoimmune thyroiditis. Their data suggest that an imbalance between immunosuppressive Treg cells and effector T cells occurs during papillary thyroid carcinogenesis. Their study identified double-negative T cells as a novel key factor involved in this process. Future research is required to recapitulate these findings, to elucidate the mechanisms by which the immune response is regulated and to evaluate if this process might be used for the therapeutical management of thyroid cancer.

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“…For the first time it's been described by Hakaru Hashimoto a Japanese surgeon who worked in Berlin, Germany (2,3).The annual incidence of HT is estimated to be around 0,3-1,5case for 1000 individuals and it more prevalent in females than in males with a ratio going from 5 until 20:1 (4,5).The same is for papillary thyroid cancer (PTC). Itis the most prevalent form of thyroid cancer around 70-80% of all thyroid cancer.It's more prevalent in females than males (6).Correlation between HT and PTC is first described from Dailey et al in 1955 (7).From that time and now it's still an open debate and the dates are still controversial. Some study report a positive correlation between 11 until 36 % (8 -11) and other didn't observed any correlation (12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Association of Hashimoto Thyroiditis (HT) with Papillary Thyroid Cancer (PTC)

2016

IJSR

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. Among the group of PTC 70 patients, the prevalence of HT was 24, 2% (17 patients), 15 females (88, 2%) and 2 males (11, 3%), which was higher than the prevalence of HT in other patients without PTC (15,3%), 12 females (92, 3%) and one male (7, 7%). Among of 30 patients with HT prevalence of PTC was 56, 6 % (17 patients), which was higher than the prevalence of PTC in other patients without HT (42,4%). However, there was no statistically significant difference (χ2 =1.98, df=1, p=0.15) between the presence of PTC in specimens with HT and the presence of PTC in other HT negative patients. There was no significant difference in age (Chi-Sq 0, 0005, p=0,18), at the time of diagnosis between PTC patients with and without HT. there is a significant difference in tumor size between patients with or without HT (Chi-Sq 7,800, p=0,02). Prevalence of microcarcinoma was higher in patient with HT than non HT 28,3%, versus 7% with a statistically significant difference (Chi-Sq =7,30 df=1, p=0.006). HT was more often observed in multifocal PTCs than in single PTCs (P=0, 07). Conclusion: In conclusion, the existing data provide inconsistent evidence favoring a causal relationship between HT and PTC. For the moment there is no valid criteria to identify those patients with HT which are at high risk for developing PTC. Careful observation and close follow-up of HT patients with nodular structure is recommended

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Hashimoto's Thyroiditis and Papillary Thyroid Carcinoma: Is There a Correlation?

Cited by 248 publications

References 37 publications

Thyroid Autoimmunity and Cancer

Thyroid Autoimmunity and Cancer

Lymphocytes and thyroid cancer: more to it than meets the eye?

Association of Hashimoto Thyroiditis (HT) with Papillary Thyroid Cancer (PTC)

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