Hashimoto’s Thyroiditis in South Indian Centre

Rajamanickam, Ramya; Shanmugavelu, Lakshmi; Sundari, S; Prasad, Hemchand Krishna; Nedunchelian, K

doi:10.1007/s12098-016-2099-x

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Diagnosis of HT was based on the classic criteria: Presence of thyroid peroxidase (TPO) antibody and/or thyroglobulin (TG) antibody, associated with primary hypothyroidism. [11] Free T4 and thyroid-stimulating hormone (TSH) were measured by electrochemiluminescent (Elecsys FT4) assay using a specific anti T4 antibody labeled with a ruthenium complex (limits of detection: 0.5 pmol/L-100 pmol/L) and monoclonal antibody directed against human TSH (0.005 µIU/mL-100 µIU/mL) using Cobas e411 analyzer, respectively. Anti-TPO antibody and anti-TG antibody were measured by electrochemiluminescent immunoassay using a recombinant antigen with polyclonal anti-TPO antibody (limits of detection: 5-600 IU/mL) and human antigen and monoclonal anti-TG antibody (limits of detection: 10-4000 IU/mL), respectively, using Cobas e411 analyzer; test number 720.…”

Section: Methodsmentioning

confidence: 99%

“…[9] A recent Indian study has demonstrated that thyroxine therapy for 6 months results in advancement of skeletal maturity by 11 months. [10] Although there are Indian studies on prevalence of HT in children, [2,11] there are no studies describing the impact of therapy on final height potential. Hence, we conducted this study with an aim to determine whether delayed diagnosis of primary hypothyroidism due to HT has an impact on catch-up growth of children and adolescents.…”

Section: Journal Of Pediatric Endocrinology and Diabetesmentioning

confidence: 99%

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Impact of delayed diagnosis on catch-up growth of children and adolescents with primary hypothyroidism due to Hashimoto’s thyroiditis

Madu

Prasad

Thiagarajan

et al. 2021

JPED

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Objectives: There is a paucity of data on impact of therapy of Hashimoto’s thyroiditis (HT) on catch-up growth. The objective of the study was to determine whether delayed diagnosis of HT and overt primary hypothyroidism has an impact on the catch-up of children and adolescents. Material and Methods: We conducted a prospective observational study over 3 years, in the thyroid clinic of a referral unit in South India. We assessed chronological age (CA), auxological parameters, clinical presentation, bone age (BA), and predicted adult height (PAH) in subjects with Hashimoto’s thyroiditis and overt primary hypothyroidism. Management and follow-up done as per standard protocols and study parameters reassessed after 1 year of therapy. Results: We recruited 38 subjects and divided them into two groups – Group 1 with BA within 2 standard deviations (SD) of CA (n = 20) and Group 2 beyond 2 SD (n = 18). During 1 year follow-up, height Z-scores were −0.1 ± 1.4 (baseline) and −0.1 ± 1.1 (endpoint) and −1.7 ± 1.7 (baseline) and −1.3 ± 1.3 (endpoint) in Groups 1 and 2, respectively. BA: CA ratio changed from 1.0 ± 0.1 to 1.0 ± 0.1 in Group 1 (P > 0.05) versus 0.7 ± 0.2 to 0.9 ± 0.1 in Group 2 (P < 0.05). The number of children who were pre-pubertal: pubertal changed from 15:5 to 11:9 in Group 1 and 14:4 to 7:11 in Group 2. For Group 1, baseline PAH Z score was −0.5 ± 1.7 and endpoint PAH Z score was −0.7 ± 1.6 versus a target height Z score of −1.1 ± 1.1 (P > 0.05); Group 2, the baseline PAH Z score −1.1 ± 1.6 and endpoint PAH Z score −2.2 ± 1.4 versus target height Z-score of −0.4 ± 1.7. Conclusion: Delayed diagnosis and treatment of juvenile autoimmune hypothyroidism results in permanent loss of height potential.

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Section: Methodsmentioning

confidence: 99%

Section: Journal Of Pediatric Endocrinology and Diabetesmentioning

confidence: 99%

Impact of delayed diagnosis on catch-up growth of children and adolescents with primary hypothyroidism due to Hashimoto’s thyroiditis

Madu

Prasad

Thiagarajan

et al. 2021

JPED

Self Cite

View full text Add to dashboard Cite

show abstract

“…The incidence of HT has a rapid growth in the last 3 decades and is 0.3–1.5 persons per 1000 individuals [ 4 , 5 ]. HT could be divided into different types including euthyroid HT, subclinical hypothyroidism, overt hypothyroidism, or hyperthyroidism based on the thyroid function [ 6 , 7 ].…”

Section: Introduction Backgroundmentioning

confidence: 99%