Hashimoto's thyroiditis presenting as Hoffman's syndrome, rhabdomyolysis and acute kidney injury

Ahmed, Gasim; Zaid, Hassan Musa; Moloney, Mairéad

doi:10.1136/bcr-2013-203269

Cited by 14 publications

(7 citation statements)

References 2 publications

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“…[ 9 ] There have been earlier case reports regarding rhabdomyolysis as the initial presentation of hypothyroidism. [ 7 , 10 , 11 ] Two among these cases were precipitated by alcohol and strenuous physical activity. [ 10 , 11 ] The exact cause of rhabdomyolysis in hypothyroidism remains unclear.…”

Section: Discussionmentioning

confidence: 99%

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An interesting case of hypothyroidism associated acute kidney injury

et al. 2023

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Muscle involvement is common in hypothyroidism. However, hypothyroidism as a causal factor for severe rhabdomyolysis and acute kidney injury (AKI) is rarely reported. We report a case of a 56-year-old Arab male who presented with unexplained acute worsening of chronic kidney disease. The patient was detected to have hypothyroidism and rhabdomyolysis on laboratory investigations. However, thyroxine replacement led to partial recovery of renal function. CPK also improved with vigorous hydration and thyroxine replacement. Although this is a rare association, in the absence of other causes of rhabdomyolysis, hypothyroidism should be suspected in patients presenting with AKI and high creatinine phospho-kinase.

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Section: Discussionmentioning

confidence: 99%

“…[ 7 , 10 , 11 ] Two among these cases were precipitated by alcohol and strenuous physical activity. [ 10 , 11 ] The exact cause of rhabdomyolysis in hypothyroidism remains unclear. Usually, an aggravating factor such as the use of lipid-lowering drugs, alcohol, exercise, or CKD has been identified.…”

Section: Discussionmentioning

confidence: 99%

An interesting case of hypothyroidism associated acute kidney injury

et al. 2023

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“…There are multiple reports of renal dysfunction attributed to rhabdomyolysis in the setting of hypothyroid associated myopathy; in some of these reports, levels of creatine kinase (CK) were significantly elevated [1][2][3][4][5][6][7][8]. In other reports, CK was only moderately elevated, though most but not all the patients had some muscle weakness, pain or stiffness [9][10][11][12][13][14][15][16]. However, renal dysfunction from hypothyroidism can also occur in the absence of rhabdomyolysis.…”

Section: Discussionmentioning

confidence: 99%

Acute Kidney Injury and Hypothyroidism in a Patient with CKD

Chandra

Haririan²,

Drachenberg³

2022

Kidney and Dialysis

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Acute kidney injury (AKI) in the setting of hypothyroidism has been documented in the literature. However, hypothyroidism is not generally considered a cause during investigation of an acute kidney injury. Most of the cases described have been reported in setting of rhabdomyolysis, while fewer cases describe AKI occurring in the absence of rhabdomyolysis. Only rarely have case reports been supplemented by renal biopsy findings to ensure other etiologies of acute kidney injury were ruled out, and none of these reports have documented changes in the kidney that could be associated with the hypothyroid state. We report a case of AKI in chronic kidney disease in the absence of rhabdomyolysis, occurring during severe hypothyroidism, that resolved completely after achievement of a euthyroid state. In addition, we provide renal biopsy findings likely associated with the hypothyroid state. We propose that evaluation of the thyroid function should be considered in any patient during evaluation of an acute kidney injury.

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“…All patients had the condition combined with facial and lower limb edema. Ahmed et al [7] even reported a patient with Hoffman's syndrome (proximal muscle weakness and pseudohypertrophy) caused by hypothyroidism, which was accompanied by rhabdomyolysis and AKI.…”

Section: Discussionmentioning

confidence: 99%