Hashimoto thyroiditis: an evidence-based guide: etiology, diagnosis and treatment

Kłubo-Gwieździńska, Joanna; Wartofsky, Léonard

doi:10.20452/pamw.16222

Cited by 60 publications

(65 citation statements)

References 107 publications

(126 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hashimoto's thyroiditis characterized by lymphocytic infiltration, which may finally lead to the progressive loss of thyroid tissue [1]. Some studies prove that HT is the outcome of the united action of genetic susceptibility and environmental factors, but the precise route is still not established [13].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The role of vitamin D for the management of depression in the Western Ukrainian population with autoimmune thyroiditis and hypothyroidism

Kamyshna

2022

Mìžnarodnij endokrinologìčnij žurnal

View full text Add to dashboard Cite

Background. Hashimoto’s thyroiditis is known to be an essential endocrine disease that affects the population and may lead to hypothyroidism. This disease is one of the most common autoimmune diseases. Hypothyroid patients frequently experience signs of depression, which is prevalent among other symptoms in hypothyroidism. Data from recent research has proved that vitamin D deficiency may cause depression manifestations in the population. The aim of our work is to study the effect of cholecalciferol on the level of depression in the Western Ukrainian population with autoimmune thyroiditis and hypothyroidism. Materials and methods. The study included 56 patients with hypothyroidism caused by autoimmune thyroiditis. We identified the severity of depression levels using the Hamilton Depression Rating Scale. Examinations were performed at the beginning and by the end of a 12-week treatment. Results. In patients of group 1 who received cholecalciferol and L-thyroxine, the level of depression on the Hamilton Depression Rating Scale decreased by 40 %, while in those who received only L-thyroxine, by 25 %. In addition, there was a significant difference between patients in groups 1 and 2 after treatment (p = 0.003). That is, additional cholecalciferol on the background of L-thyroxine was more effective than therapy with L-thyroxine alone. Analysis of the effect of treatment in group 1 with the additional administration of cholecalciferol on the background of L-thyroxine has shown that depression disappeared in 21.4 % of patients. In addition, there was a decrease in depression in other participants from this group. Thus, in the remaining patients, the severity of depressive manifestations decreased from moderate to mild depressive disorder. At the same time, after treatment with L-thyroxine alone, depressive disorder of moderate severity decreased from 78.6 to 35.7 %, but complete disappearance of depression in this group of patients after treatment was not observed. Conclusions. Vitamin D supplementation should be administered in patients suffering from autoimmune thyroiditis and hypothyroidism, which may correct depression disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Hashimoto's thyroiditis is known to be an essential endocrine disease that affects the population and may lead to hypothyroidism. This disease is one of the most commonly spread autoimmune diseases [1]. Hypothyroid patients frequently experience features of depression which is prevalent among other symptoms in hypothyroidism [2].…”

Section: Introductionmentioning

confidence: 99%

The role of vitamin D for the management of depression in the Western Ukrainian population with autoimmune thyroiditis and hypothyroidism

Kamyshna

2022

Mìžnarodnij endokrinologìčnij žurnal

View full text Add to dashboard Cite

show abstract

“…Cells of Hashimoto's thyroiditis appear immune reactive to high molecular weight keratin or p63. Elevated kappa/lambda ratio occurs due to enhanced production of kappa light chains secreted by plasma cells [4,5] . Admixed infiltrate of T lymphocytes and B lymphocytes appears polyclonal [4,5].…”

Section: Bajaj Amentioning

confidence: 99%

“…Elevated kappa/lambda ratio occurs due to enhanced production of kappa light chains secreted by plasma cells [4,5] . Admixed infiltrate of T lymphocytes and B lymphocytes appears polyclonal [4,5]. Ultrastructural examination exhibits oncocytic cells incorporated with enlarged mitochondria and decimated cellular organelles [4,5].…”

Section: Bajaj Amentioning

confidence: 99%

Tenacious and Unmitigated–Hashimoto’s Thyroiditis

Bajaj¹

2022

MPPHE

View full text Add to dashboard Cite

show abstract

“…Several genes have been involved in HT pathogenesis, including genes of the immune response (coded in the Human Leukocyte Antigen (HLA) complex) and thyroid function. Other immunoregulatory genes are involved in the development of HT, including the single nucleotide polymorphisms (SNPs) in cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), protein tyrosine phosphatase non-receptor type 22 (PTPN22), and CD40 [ 2 , 4 , 6 , 7 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolic Characteristics of Hashimoto’s Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management—An Overview

Mikulska

Karaźniewicz−Łada

Filipowicz

et al. 2022

IJMS

View full text Add to dashboard Cite

Hashimoto’s thyroiditis (HT) is the most common autoimmune disease and the leading cause of hypothyroidism, in which damage to the thyroid gland occurs due to the infiltration of lymphocytes. It is characterized by increased levels of antibodies against thyroid peroxidase and thyroglobulin. In this review, we present the metabolic profile, the effectiveness of micronutrient supplementation and the impact of dietary management in patients with HT. For this current literature review, the databases PubMed, Cochrane, Medline and Embase were reviewed from the last ten years until March 2022. This article provides a comprehensive overview of recent randomized controlled trials, meta-analyses, and clinical trials. Many patients with HT, even in the euthyroid state, have excess body weight, metabolic disorders, and reduced quality of life. Due to frequent concomitant nutritional deficiencies, the role of vitamin D, iodine, selenium, magnesium, iron and vitamin B12 is currently debated. Several studies have underlined the benefits of vitamin D and selenium supplementation. There is still no specific diet recommended for patients with HT, but a protective effect of an anti-inflammatory diet rich in vitamins and minerals and low in animal foods has been suggested. There is insufficient evidence to support a gluten-free diet for all HT patients. Pharmacotherapy, along with appropriate nutrition and supplementation, are important elements of medical care for patients with HT. The abovementioned factors may decrease autoantibody levels, improve thyroid function, slow down the inflammatory process, maintain proper body weight, relieve symptoms, and prevent nutritional deficiencies and the development of metabolic disorders in patients with HT.

show abstract

Hashimoto thyroiditis: an evidence-based guide: etiology, diagnosis and treatment

Cited by 60 publications

References 107 publications

The role of vitamin D for the management of depression in the Western Ukrainian population with autoimmune thyroiditis and hypothyroidism

The role of vitamin D for the management of depression in the Western Ukrainian population with autoimmune thyroiditis and hypothyroidism

Tenacious and Unmitigated–Hashimoto’s Thyroiditis

Metabolic Characteristics of Hashimoto’s Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management—An Overview

Contact Info

Product

Resources

About