Hashimoto thyroiditis is more frequent than expected when diagnosed by cytology which uncovers a pre-clinical state

Staii, Anca; Mirocha, Sarah; Todorova‐Koteva, Kristina; Glinberg, Simone L.; Jaume, Juan Carlos

doi:10.1186/1756-6614-3-11

Cited by 83 publications

(65 citation statements)

References 26 publications

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“…1 The mean age at presentation was 40.4years which is similar to a study carried out by Staii et al 14 The cytological diagnosis of autoimmune thyroiditis ( fig. 3 &4) was made in 44.2% comprising 42 cases (24 lymphocytic thyroiditis and 18 Hashimoto thyroiditis).…”

Section: Discussionsupporting

confidence: 71%

“…Hence, detection of autoimmune thyroiditis in nodular goitre becomes clinically significant. [15][16] As with other studies, 14 an important aspect of this study is that most patients with autoimmune thyroiditis were pre-menopausal females with high TSH levels. The risk of miscarriage, fetal and neonatal death increases with higher TSH levels.…”

Section: Discussionmentioning

confidence: 84%

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Fine needle aspiration cytology of thyroid and its correlation with serological findings

Karki

Shrestha

2017

J Pathol Nep

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Background: Thyroid autoimmunity can cause several forms of thyroid disorders i.e. Grave's disease, Hashimoto's thyroiditis, atrophic autoimmune thyroiditis, post-partum thyroidits etc. Cytological diagnosis may be sometimes difficult is some cases. In such conditions, cytology along with serological tests aid at reaching a correct diagnosis. Hence, this study was undertaken to evaluate the serum level of anti-TPO antibody with respect to serum concentrations of thyroid hormones and its importance in diagnosing autoimmune thyroiditis. Results: Ninety-five thyroid FNAC was included in the study, which comprises of 16.8 % males and 83.2% females with a M: F 1: 4.9. Maximum number of cases was seen in the age range 21-30 years (25.3%), mean age being 40.4years. The cytological diagnosis comprised colloid goiter(43.2%), lymphocytic thyroiditis(25.3%), Hashimoto thyroiditis(18.9%). Out of 42 cases of autoimmune thyroiditis diagnosed cytologically, 16 (38%) were hypothyroid, 4 (9.5%) hyperthyroid, 8 (19%) sub-clinical hypothyroid and 14 (33.5%) were euthyroid. The sensitivity and specificity of positive anti TPO in correctly identifying autoimmune thyroiditis was 85.7% and 79.2% respectively. The positive and negative predictive value for the test was 76.5% and 87.5% respectively. Conclusion

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 84%

Fine needle aspiration cytology of thyroid and its correlation with serological findings

Karki

Shrestha

2017

J Pathol Nep

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“…The presence of HT in our study on histopathology result was 19,3 %. In the study of Staii et al the prevalence of HT diagnosed by cytology was13.4% (19). Prevalence of papillary thyroid microcarcinoma (PTMC) was higher in patient with HT than non HT 28,3% versus 7% with a In conclusion, the existing data provide inconsistent evidence favoring a causal relationship between HT and PTC.…”

Section: Discussionmentioning

confidence: 69%

Association of Hashimoto Thyroiditis (HT) with Papillary Thyroid Cancer (PTC)

2016

IJSR

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. Among the group of PTC 70 patients, the prevalence of HT was 24, 2% (17 patients), 15 females (88, 2%) and 2 males (11, 3%), which was higher than the prevalence of HT in other patients without PTC (15,3%), 12 females (92, 3%) and one male (7, 7%). Among of 30 patients with HT prevalence of PTC was 56, 6 % (17 patients), which was higher than the prevalence of PTC in other patients without HT (42,4%). However, there was no statistically significant difference (χ2 =1.98, df=1, p=0.15) between the presence of PTC in specimens with HT and the presence of PTC in other HT negative patients. There was no significant difference in age (Chi-Sq 0, 0005, p=0,18), at the time of diagnosis between PTC patients with and without HT. there is a significant difference in tumor size between patients with or without HT (Chi-Sq 7,800, p=0,02). Prevalence of microcarcinoma was higher in patient with HT than non HT 28,3%, versus 7% with a statistically significant difference (Chi-Sq =7,30 df=1, p=0.006). HT was more often observed in multifocal PTCs than in single PTCs (P=0, 07). Conclusion: In conclusion, the existing data provide inconsistent evidence favoring a causal relationship between HT and PTC. For the moment there is no valid criteria to identify those patients with HT which are at high risk for developing PTC. Careful observation and close follow-up of HT patients with nodular structure is recommended

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“…In the UK, Tunbridge et al (35) reported an overall HT prevalence of 0.8%. However, diagnosis based fine needle aspiration biopsy study; the cytology of HT seems to be much more prevalent, at 13.4% (36). This difference may be partially explained by the fact that for diagnosing clinical HT, abnormally elevated TSH, low thyroid hormones (34,35) and the confirmatory presence of thyroid autoantibodies are usually accounted for.…”

Section: Clinical Manifestationmentioning

confidence: 95%