Hashitoxicosis in children: Clinical features and natural history

Nabhan, Zeina M.; Kreher, Nerissa C.; Eugster, Erica A.

doi:10.1016/j.jpeds.2004.10.070

Cited by 77 publications

(60 citation statements)

References 18 publications

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“…However, a twofold increase in incidence over a 10-year period up until 1998 was reported from Hong Kong (9). We expect that virtually all treated patients had autoimmune thyroid disease with most affected by Graves' disease rather than 'Hashitoxicosis' (10). The increase in RI treatments and the increase as a percentage of the overall total (children and adults) may therefore reflect the fact that autoimmune thyroid disease is becoming more common in young people.…”

Section: Discussionmentioning

confidence: 96%

Increasing use of radioiodine in young people with thyrotoxicosis in Great Britain

Turner

Driver

Salotti

et al. 2012

European Journal of Endocrinology

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Objective: Radioiodine (RI) is an important therapeutic option in young patients with thyrotoxicosis. We wanted to determine whether RI is being used more frequently in this age group. Design: National survey of Great Britain (England, Wales and Scotland). Methods: Sixty-one medical physics departments were asked to provide the age and number of patients with thyrotoxicosis !21 years treated with RI (1990RI ( -2008. Information on the total number of RI treatments for thyrotoxicosis was also collected. Results: Forty-three departments (70%), with representation from 21 of the 25 most populous areas of Great Britain, provided data on 69 258 treatments. The number of treatments recorded on patients !21 years during this period was 560 (0.9%). The frequency of treatments in young people as a percentage of the total increased from 0.2% in 1990 to 1.5% in 2008 (P!0.001). When the 18 centres submitting at least 17 years of data were analysed, a similar pattern was observed. The maximum number of young people treated was greatest in 2008 (62) with a fall in the youngest age at which RI was administered from 18 years (1990) to 11 years (2008). Conclusions: A rising proportion of patients with thyrotoxicosis receiving RI are in those !21 years. This is largely due to an increase in the number of young people treated with a reduction in the minimum age at RI administration. We suspect that European clinicians are becoming more comfortable with RI treatment in young people with thyrotoxicosis, although a changing incidence is a potential contributing factor.

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Section: Discussionmentioning

confidence: 96%

Increasing use of radioiodine in young people with thyrotoxicosis in Great Britain

Turner

Driver

Salotti

et al. 2012

European Journal of Endocrinology

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“…Though, the disease can demonstrate biochemical hyperthyroidism, which is called Hashitoxicosis, due to inappropriate release of remaining thyroid hormone. RAI scans can differentiate between the transient hyperthyroidism of Hashitoxicosis and Graves' disease [11]. With scanning, Hashitoxicosis exhibits low uptake, while Graves' disease exhibits higher uptake.…”

Section: Discussionmentioning

confidence: 99%

Radioactive Iodine Scanning is Not Beneficial but its Use Persists for Euthyroid Patients

Panneerselvan

Schneider

Sippel

et al. 2013

Journal of Surgical Research

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“…La causa más comúnmente descrita de HT es la enfermedad de Graves (95%) 14 , en nuestro estudio correspondió sólo al 73% de los casos; esto pudiera explicarse porque en 3 pacientes no se pudo precisar la etiología del HT. Otras causas son la tiroiditis linfocitaria crónica que en su fase inicial produce liberación de hormonas tiroideas por destrucción celular (Hashitoxicosis) 15 , que correspondió en nuestros niños al 15,3% de las etiologías; se ha descrito también HT inducido por yodo, Síndrome de McCune-Albright, cán-cer de tiroides, hipersecreción de TSH e inges-tión de hormonas tiroideas 16 . El HT neonatal puede ocurrir en hijos de madre con EG, el cual es transitorio o ser secundario a HT congénito no autoinmune.…”

Section: Discussionunclassified

Hipertiroidismo en niños y adolescentes

et al. 2009

Rev. chil. pediatr.

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Hyperthyroidism in children and adolescentsBackground: Hyperthyroidism (HT) prevalence is 0.1/100,000 children and 1/100,000 adolescents and Graves Disease is the most frequent etiology. Objective: To evaluate the clinical presentation, etiology and treatment in hyperthyroid children. Method: Retrospective review of clinical charts of children under 15 years-old, between June 2004 and August 2005. Hyperthyroidism diagnosis was performed with suppressed TSH and increased thyroid hormones levels. Etiological study was done by TRAb, ATPO, ATG, thyroid echotomography and I

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Hashitoxicosis in children: Clinical features and natural history

Cited by 77 publications

References 18 publications

Increasing use of radioiodine in young people with thyrotoxicosis in Great Britain

Increasing use of radioiodine in young people with thyrotoxicosis in Great Britain

Radioactive Iodine Scanning is Not Beneficial but its Use Persists for Euthyroid Patients

Hipertiroidismo en niños y adolescentes

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