Hastanede uzun süreli yatan hastalarda Clostridium difficile  kolonizasyonunun araştırılması

Öksüz, Şükrü; Daniş, Ayşe; Öztürk, Elif; Çalışkan, Emel; Akar, Nida; Sungur, Mehmet Alı

doi:10.21673/anadoluklin.298926

Anadolu Kliniği Tıp Bilimleri Dergisi

2017

DOI: 10.21673/anadoluklin.298926

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Hastanede uzun süreli yatan hastalarda Clostridium difficile kolonizasyonunun araştırılması

Şükrü Öksüz

Ayşe Daniş

Elif Öztürk

et al.

Abstract: Clostridium difficile antibiyotik ile ilişkili ishal ve kolitlerin en önemli nedenidir. Dünyada önemli bir sağlık sorunu olan antibiyotik ile ilişkili ishal olgularının %15-30'undan sorumlu tutulmaktadır. Clostridium difficile enfeksiyonu hafif ishalden toksik megakolon oluşumuna kadar varan, değişken bir klinik tablo sergilemektedir İleri yaş, hastanede yatma ve özgün antibiyotiklere maruz kalma Clostridium difficile enfeksiyonu için en yaygın risk faktörleridir. Bu çalışmada uzun süre hastanede yatan hastala… Show more

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2024

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Evaluation of different algorithm schemes in the laboratory diagnosis of Clostridioides difficile

Trak,

Yeşiloğlu,

Öngen

2024

Cukurova Medical Journal

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Purpose: Clostridioides difficile infection is a major cause of antibiotic-associated diarrhea, particularly in healthcare settings. This study aims to evaluate the applicability, speed, cost-effectiveness, and diagnostic accuracy of different laboratory algorithm schemes for C. difficile infection in a routine clinical setting. Materials and Methods: A total of 479 stool samples from patients suspected of having C. difficile infection were analyzed using glutamate dehydrogenase enzyme immunoassay, toxin A/B enzyme immunoassay, toxigenic culture, and real-time polymerase chain reaction. The sensitivity, cost-effectiveness and overall diagnostic accuracy of these methods were assessed when applied in different algorithmic sequences. Results: Of the 479 samples, 52 were positive for glutamate dehydrogenase antigen. Polymerase chain reaction exhibited the highest sensitivity, detecting C. difficile in 55.8% of glutamate dehydrogenase -positive samples, followed by toxigenic culture at 25.0%, and toxin A/B enzyme immunoassay at 23.1%. The combination of glutamate dehydrogenase screening followed by polymerase chain reaction was the most effective diagnostic approach, offering both high sensitivity and cost-effectiveness. Conclusion: The study emphasizes the importance of a multi-step diagnostic algorithm, particularly starting with glutamate dehydrogenase screening followed by PCR, to improve the accuracy and cost-effectiveness of C. difficile infection diagnosis. These findings support the need for tailored diagnostic strategies based on laboratory resources and patient population characteristics.

show abstract

Evaluation of different algorithm schemes in the laboratory diagnosis of Clostridioides difficile

Trak,

Yeşiloğlu,

Öngen

2024

Cukurova Medical Journal

View full text Add to dashboard Cite

show abstract

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Hastanede uzun süreli yatan hastalarda Clostridium difficile kolonizasyonunun araştırılması

Cited by 1 publication

References 10 publications

Evaluation of different algorithm schemes in the laboratory diagnosis of Clostridioides difficile

Evaluation of different algorithm schemes in the laboratory diagnosis of Clostridioides difficile

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