Hataedock treatment has preventive therapeutic effects for atopic dermatitis through skin barrier protection in Dermatophagoides farinae -induced NC/Nga mice

Inhibitory effect of Carnosol on UVB-induced inflammation via inhibition of STAT3

“…It was reported that hypochlorous acid and tofacitinib downregulate IgE and cytokine level in a murine atopic dermatitis model (Fukuyama et al 2018). It has been also reported that Hataedock, Quercetin, Resveratrol, and K112PC-5 possess anti-inflammatory effects by inhibiting NO production and expression of iNOS and COX-2 (Kang et al 2008; Cichocki et al 2008; Cha et al 2016, 2017). These data indicating that carnosol could be useful for UVB-induced inflammatory skin damages.…”

CZ2HF mitigates β-amyloid 25-35 fragment-induced learning and memory impairment through inhibition of neuroinflammation and apoptosis in rats

“…Agents. donepezil hydrochloride (1511010) was obtained from Affiliated Hospital of Zunyi Medical University (Zunyi, China), Aβ [25][26][27][28][29][30][31][32][33][34][35] (the amino acid sequence is Gly-Ser-Asn-Lys-Gly-A la-Ile-Ile-Gly-Leu-Met) was purchased from Sigma-Aldrich (cat. no.…”

“…All experiments were approved by the Ethics committee and performed according to the current guide for the care and use of laboratory animal standard, which was set up by Zunyi Medical University Animal Studies committee (argument number [2015] 2-043). The rats were randomly divided into 7 groups as follows: i) Sham; ii) sham+cZ2HF (400 mg/kg); iii) model (Aβ [25][26][27][28][29][30][31][32][33][34][35] ); iv) Aβ [25][26][27][28][29][30][31][32][33][34][35] +cZ2HF (100 mg/kg); v) Aβ [25][26][27][28][29][30][31][32][33][34][35] +cZ2HF (200 mg/kg); vi) Aβ [25][26][27][28][29][30][31][32][33][34][35] +cZ2HF (400 mg/kg); and vii) Aβ 25-35 +donepezil (1.0 mg/kg) as the positive drug group (n=14 rats per group. Briefly, Aβ [25][26][27]…”

“…Subsequently, Sd rats were anesthetized with an intraperitoneal injection of 2% pentobarbital sodium, the rat's brain was fixed a stereotaxic device, and the following hippocampus needle coordinates were used: 3.5 mm posterior to the bregma, 2.5 mm lateral to the sagittal suture, 3.5 mm beneath the surface of brain. The needle was retained in the bilateral hippocampi for 5 min and the 5 µl Aβ [25][26][27][28][29][30][31][32][33][34][35] was injected. Various doses of cZ2HF were administered orally daily for a continuous period for 15 days.…”

“…However, whether cZ2HF is capable of alleviating learning and memory impairment in Alzheimer's disease (Ad) remains to be elucidated. The present study was designed to explore the effect and mechanism of cZ2HF on β-amyloid [25][26][27][28][29][30][31][32][33][34][35] )-induced impairment in the learning and memory of rats. Morris water maze test was used to determine spatial learning and memory ability in Aβ 25-35 -induced Ad rats and hippocampal neuronal damage and apoptosis were observed using hematoxylin and eosin staining, Nissl staining and terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling (TUNEL) assays, respectively.…”